热门
Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication
文献类型：期刊论文
| 作者 | Wang, MS; Zhang, RW; Su, LY; Li, Y; Peng, MS; Liu, HQ; Zeng, L; Irwin, DM; Du, JL; Yao, YG |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 26期号:5页码:556-573 |
| 关键词 | FLICKER FUSION FREQUENCY GALLUS-GALLUS-DOMESTICUS NUCLEAR RECEPTOR NR2E3 GANGLION-CELLS MOLECULAR EVOLUTION NATURAL-SELECTION KNOBLOCH-SYNDROME GENETIC-VARIATION SEQUENCING DATA LIGHT RESPONSE |
| 通讯作者 | Wu, DD ; Zhang, YP (reprint author), Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Yunnan Lab Mol Biol Domest Anim, State Key Lab Genet Resources & Evolut, Kunming 650223, Yunnan, Peoples R China. ; Wu, DD (reprint author), Chinese Acad Sci & Yunnan Prov, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Yunnan, Peoples R China. ; Zhang, YP (reprint author), Unisvers Chinese Acad Sci, Kunming Coll Life Sci, Kunming 650204, Yunnan, Peoples R China. ; Zhang, YP (reprint author), Yunnan Univ, Lab Conservat & Utilizat Bioresource, Kunming 650091, Yunnan, Peoples R China.,wudongdong@mail.kiz.ac.cn ; zhangyp@mail.kiz.ac.cn |
| 英文摘要 | As noted by Darwin, chickens have the greatest phenotypic diversity of all birds, but an interesting evolutionary difference between domestic chickens and their wild ancestor, the Red Junglefowl, is their comparatively weaker vision. Existing theories suggest that diminished visual prowess among domestic chickens reflect changes driven by the relaxation of functional constraints on vision, but the evidence identifying the underlying genetic mechanisms responsible for this change has not been definitively characterized. Here, a genome-wide analysis of the domestic chicken and Red Junglefowl genomes showed significant enrichment for positively selected genes involved in the development of vision. There were significant differences between domestic chickens and their wild ancestors regarding the level of mRNA expression for these genes in the retina. Numerous additional genes involved in the development of vision also showed significant differences in mRNA expression between domestic chickens and their wild ancestors, particularly for genes associated with phototransduction and photoreceptor development, such as RHO (rhodopsin), GUCA1A, PDE6B and NR2E3. Finally, we characterized the potential role of the VIT gene in vision, which experienced positive selection and downregulated expression in the retina of the village chicken. Overall, our results suggest that positive selection, rather than relaxation of purifying selection, contributed to the evolution of vision in domestic chickens. The progenitors of domestic chickens harboring weaker vision may have showed a reduced fear response and vigilance, making them easier to be unconsciously selected and/or domesticated. |
| 学科主题 | Cell Biology |
| WOS标题词 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000377449200007 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4025]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Wang, MS,Zhang, RW,Su, LY,et al. Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication[J]. CELL RESEARCH,2016,26(5):556-573. |
| APA | Wang, MS.,Zhang, RW.,Su, LY.,Li, Y.,Peng, MS.,...&Zhang, YP.(2016).Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication.CELL RESEARCH,26(5),556-573. |
| MLA | Wang, MS,et al."Positive selection rather than relaxation of functional constraint drives the evolution of vision during chicken domestication".CELL RESEARCH 26.5(2016):556-573. |
入库方式： OAI收割
来源：上海神经科学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。