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Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy
文献类型：期刊论文
| 作者 | Feng, SJ; Ma, SR; Jia, CX; Su, YJ; Yang, SL; Zhou, KC; Liu, YN; Cheng, J; Lu, DG; Fan, L |
| 刊名 | EMBO REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 17期号:5页码:682-694 |
| 关键词 | HIPPOCAMPAL-NEURONS EPILEPTIFORM ACTIVITY SMALL-MOLECULE STEM-CELLS BRAIN TRANSPORTER ACTIVATION EXPRESSION RECEPTOR SEIZURE |
| 通讯作者 | Wang, YZ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Lab Neural Signal Transduct,Inst Neurosci, Shanghai, Peoples R China.,yzwang@ion.ac.cn |
| 英文摘要 | Sonic hedgehog (Shh), both as a mitogen and as a morphogen, plays an important role in cell proliferation and differentiation during early development. Here, we show that Shh inhibits glutamate transporter activities in neurons, rapidly enhances extracellular glutamate levels, and affects the development of epilepsy. Shh is quickly released in response to epileptic, but not physiological, stimuli. Inhibition of neuronal glutamate transporters by Shh depends on heterotrimeric G protein subunit G(i) and enhances extracellular glutamate levels. Inhibiting Shh signaling greatly reduces epileptiform activities in both cell cultures and hippocampal slices. Moreover, pharmacological or genetic inhibition of Shh signaling markedly suppresses epileptic phenotypes in kindling or pilocarpine models. Our results suggest that Shh contributes to the development of epilepsy and suppression of its signaling prevents the development of the disease. Thus, Shh can act as a modulator of neuronal activity, rapidly regulating glutamate levels and promoting epilepsy. |
| WOS标题词 | Biochemistry & Molecular Biology ; Cell Biology |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000375617400011 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4026]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Feng, SJ,Ma, SR,Jia, CX,et al. Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy[J]. EMBO REPORTS,2016,17(5):682-694. |
| APA | Feng, SJ.,Ma, SR.,Jia, CX.,Su, YJ.,Yang, SL.,...&Wang, YZ.(2016).Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy.EMBO REPORTS,17(5),682-694. |
| MLA | Feng, SJ,et al."Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy".EMBO REPORTS 17.5(2016):682-694. |
入库方式： OAI收割
来源：上海神经科学研究所
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