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Genetic lineage tracing identifies endocardial origin of liver vasculature
文献类型：期刊论文
| 作者 | Zhang, H; Pu, WJ; Tian, XY; Huang, XZ; He, LJ; Liu, QZ; Li, Y; Zhang, LB; He, L; Liu, K |
| 刊名 | NATURE GENETICS
 |
| 出版日期 | 2016 |
| 卷号 | 48期号:5页码:537-537 |
| 关键词 | ENDOTHELIAL-CELLS CORONARY-ARTERIES MOLECULAR-MECHANISMS TRANSCRIPTION FACTOR BLOOD-VESSELS NF-ATC VEGF-A ANGIOGENESIS HEART SIGNALS |
| 通讯作者 | Zhou, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Key Lab Nutr & Metab, Inst Nutr Sci,Grad Sch, Shanghai, Peoples R China. ; Zhou, B (reprint author), ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China. ; Zhou, B (reprint author), Chinese Acad Sci, State Key Lab Neurosci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci,Shanghai Inst Biol Sci, Shanghai, Peoples R China.,zhoubin@sibs.ac.cn |
| 英文摘要 | The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the developmental program of hepatic vessel formation and the embryonic origin of the liver vasculature remain unknown. Here we show in mouse that endocardial cells form a primitive vascular plexus surrounding the liver bud and subsequently contribute to a substantial portion of the liver vasculature. Using intersectional genetics, we demonstrate that the endocardium of the sinus venosus is a source for the hepatic plexus. Inhibition of endocardial angiogenesis results in reduced endocardial contribution to the liver vasculature and defects in liver organogenesis. We conclude that a substantial portion of liver vessels derives from the endocardium and shares a common developmental origin with coronary arteries. |
| WOS标题词 | Genetics & Heredity |
| 学科主题 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000374834100013 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4027]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, H,Pu, WJ,Tian, XY,et al. Genetic lineage tracing identifies endocardial origin of liver vasculature[J]. NATURE GENETICS,2016,48(5):537-537. |
| APA | Zhang, H.,Pu, WJ.,Tian, XY.,Huang, XZ.,He, LJ.,...&Zhou, B.(2016).Genetic lineage tracing identifies endocardial origin of liver vasculature.NATURE GENETICS,48(5),537-537. |
| MLA | Zhang, H,et al."Genetic lineage tracing identifies endocardial origin of liver vasculature".NATURE GENETICS 48.5(2016):537-537. |
入库方式： OAI收割
来源：上海神经科学研究所
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