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Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: large-scale observational study

文献类型:期刊论文

作者Guan, J; Yi, HL; Zou, JY; Meng, LL; Tang, XL; Zhu, HM; Yu, DZ; Zhou, HQ; Su, KM; Yang, MP
刊名THORAX
出版日期2016
卷号71期号:4页码:347-355
关键词POSITIVE AIRWAY PRESSURE RANDOMIZED CONTROLLED-TRIALS METABOLIC CONSEQUENCES CARDIOVASCULAR-DISEASE HEART HEALTH RISK-FACTORS INSULIN-RESISTANCE VASCULAR-DISEASE MECHANISMS OBESITY
通讯作者Yin, SK (reprint author), Shanghai Jiao Tong Univ, Peoples Hosp 6, Therapy Ctr Obstruct Sleep Apnea, Dept Otolaryngol,Otolaryngol Inst, 600 Yishan Rd, Shanghai 200233, Peoples R China.,skyin@sjtu.edu.cn
英文摘要Background Dyslipidaemia is an intermediary exacerbation factor for various diseases but the impact of obstructive sleep apnoea (OSA) on dyslipidaemia remains unclear. Methods A total of 3582 subjects with suspected OSA consecutively admitted to our hospital sleep centre were screened and 2983 (2422 with OSA) were included in the Shanghai Sleep Health Study. OSA severity was quantified using the apnoea-hypopnea index (AHI), the oxygen desaturation index and the arousal index. Biochemical indicators and anthropometric data were also collected. The relationship between OSA severity and the risk of dyslipidaemia was evaluated via ordinal logistic regression, restricted cubic spline (RCS) analysis and multivariate linear regressions. Results The RCS mapped a nonlinear dose-effect relationship between the risk of dyslipidaemia and OSA severity, and yielded knots of the AHI (9.4, 28.2, 54.4 and 80.2). After integrating the clinical definition and RCS-selected knots, all subjects were regrouped into four AHI severity stages. Following segmented multivariate linear modelling of each stage, distinguishable sets of OSA risk factors were quantified: low-density lipoprotein cholesterol (LDL-C), apolipoprotein E and high-density lipoprotein cholesterol (HDL-C); body mass index and/or waist to hip ratio; and HDL-C, LDL-C and triglycerides were specifically associated with stage I, stages II and III, and stages II-IV with different OSA indices. Conclusions Our study revealed the multistage and non-monotonic relationships between OSA and dyslipidaemia and quantified the relationships between OSA severity indexes and distinct risk factors for specific OSA severity stages. Our study suggests that a new interpretive and predictive strategy for dynamic assessment of the risk progression over the clinical course of OSA should be adopted.
学科主题Respiratory System
WOS标题词Respiratory System
语种英语
WOS记录号WOS:000372285700009
源URL[http://ir.sibs.ac.cn/handle/331001/4032]  
专题上海神经科学研究所_神经所(总)
推荐引用方式
GB/T 7714
Guan, J,Yi, HL,Zou, JY,et al. Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: large-scale observational study[J]. THORAX,2016,71(4):347-355.
APA Guan, J.,Yi, HL.,Zou, JY.,Meng, LL.,Tang, XL.,...&Yin, SK.(2016).Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: large-scale observational study.THORAX,71(4),347-355.
MLA Guan, J,et al."Distinct severity stages of obstructive sleep apnoea are correlated with unique dyslipidaemia: large-scale observational study".THORAX 71.4(2016):347-355.

入库方式: OAI收割

来源:上海神经科学研究所

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