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Smooth muscle origin of postnatal 2nd CVP is pre-determined in early embryo
文献类型：期刊论文
| 作者 | Liu, QZ; Zhang, H; Tian, XY; He, LJ; Huang, XZ; Tan, Z; Yan, Y; Evans, SM; Wythe, JD; Zhou, B |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2016 |
| 卷号 | 471期号:4页码:430-436 |
| 关键词 | EPICARDIUM-DERIVED CELLS CORONARY-ARTERIES ENDOTHELIAL-CELLS VASCULAR REGENERATION HEART ANGIOGENESIS LINEAGE ADULT FATE FORM |
| 通讯作者 | Zhou, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai 200031, Peoples R China.,zhoubin@sibs.ac.cn |
| 英文摘要 | Recent identification of the neonatal 2nd coronary vascular population (2nd CVP) suggests that a subset of these vessels form de novo and mature in the inner myocardial wall of the postnatal heart. However, the origin of smooth muscle cells (SMCs) in the postnatal 2nd CVP remains undetermined. Using a tamoxifen-inducible Wt1-CreER driver and a Rosa26-RFP reporter line, we traced the lineage of epicardial cells to determine if they contribute to SMCs of the 2nd CVP: Late embryonic and postnatal induction of Wt1-CreER activity demonstrated that at these stages Wt1-labeled epicardium does not significantly migrate into the myocardium to form SMCs. However, following tamoxifen treatment at an early embryonic stage (E10.5), we detected Wt1 descendants (epicardium-derived cells, or EPDCs) in the outer myocardial wall at E17.5. When the 2nd CVP forms and remodels at postnatal stage, these early labeled EDPCs re-migrate deep into the inner myocardial wall and contribute to 2nd CVP-SMCs in the adult heart. Our findings reveal that SMCs in the postnatal 2nd CVP are pre-specified as EPDCs from the earliest wave of epicardial cell migration. Rather than the re-activation and migration of epicardial cells at later stages, these resident EPDCs mobilize and contribute to smooth muscle of the 2nd CVP during postnatal development. (C) 2016 Elsevier Inc. All rights reserved. |
| WOS标题词 | Biochemistry & Molecular Biology ; Biophysics |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000373242600007 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4033]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Liu, QZ,Zhang, H,Tian, XY,et al. Smooth muscle origin of postnatal 2nd CVP is pre-determined in early embryo[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,471(4):430-436. |
| APA | Liu, QZ.,Zhang, H.,Tian, XY.,He, LJ.,Huang, XZ.,...&Zhou, B.(2016).Smooth muscle origin of postnatal 2nd CVP is pre-determined in early embryo.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,471(4),430-436. |
| MLA | Liu, QZ,et al."Smooth muscle origin of postnatal 2nd CVP is pre-determined in early embryo".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 471.4(2016):430-436. |
入库方式： OAI收割
来源：上海神经科学研究所
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