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Inverted optical intrinsic response accompanied by decreased cerebral blood flow are related to both neuronal inhibition and excitation
文献类型：期刊论文
| 作者 | Ma, ZG; Cao, PJ; Sun, PC; Zhao, LN; Li, LM; Tong, SB; Lu, YL; Yan, Y; Chen, Y; Chai, XY |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6页码:21627 |
| 关键词 | NEGATIVE BOLD RESPONSE PRIMARY SOMATOSENSORY CORTEX DEPENDENT FMRI SIGNALS HUMAN VISUAL-CORTEX HEMODYNAMIC-RESPONSE HUMAN BRAIN ELECTRICAL-STIMULATION OXYGEN-METABOLISM INITIAL DIP 7 T |
| 通讯作者 | Chen, Y ; Chai, XY (reprint author), Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China.,yao.chen@sjtu.edu.cn ; xychai@sjtu.edu.cn |
| 英文摘要 | Negative hemodynamic response has been widely reported in blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies, however its origin is still controversial. Optical intrinsic signal (OIS) imaging can be used to study brain activity by simultaneously recording hemodynamic signals at different wavelengths with high spatial resolution. In this study, we found transcorneal electrical stimulation (TcES) could elicit both positive OIS response (POR) and negative OIS response (NOR) in cats' visual cortex. We then investigated the property of this negative response to TcES and its relationship with cerebral blood flow (CBF) and neuronal activity. Results from laser speckle contrast imaging showed decreased CBF in the NOR region while increased CBF in the POR region. Both planar and laminar electrophysiological recordings in the middle (500-700 mu m) cortical layers demonstrated that decreased and increased neuronal activities were coexisted in the NOR region. Furthermore, decreased neuronal activity was also detected in the deep cortical layers in the NOR region. This work provides evidence that the negative OIS together with the decreased CBF should be explained by mechanisms of both neuronal inhibition and excitation within middle cortical layers. Our results would be important for interpreting neurophysiological mechanisms underlying the negative BOLD signals. |
| WOS标题词 | Science & Technology - Other Topics |
| 学科主题 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000369832300001 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4039]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Ma, ZG,Cao, PJ,Sun, PC,et al. Inverted optical intrinsic response accompanied by decreased cerebral blood flow are related to both neuronal inhibition and excitation[J]. SCIENTIFIC REPORTS,2016,6:21627. |
| APA | Ma, ZG.,Cao, PJ.,Sun, PC.,Zhao, LN.,Li, LM.,...&Chai, XY.(2016).Inverted optical intrinsic response accompanied by decreased cerebral blood flow are related to both neuronal inhibition and excitation.SCIENTIFIC REPORTS,6,21627. |
| MLA | Ma, ZG,et al."Inverted optical intrinsic response accompanied by decreased cerebral blood flow are related to both neuronal inhibition and excitation".SCIENTIFIC REPORTS 6(2016):21627. |
入库方式： OAI收割
来源：上海神经科学研究所
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