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Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs
文献类型：期刊论文
| 作者 | Lyu, JW; Yuan, B; Cheng, TL; Qiu, ZL; Zhou, WH |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016 |
| 卷号 | 6页码:20392 |
| 关键词 | RETT-SYNDROME BDNF TRANSCRIPTION DENDRITIC GROWTH MOUSE MODEL EXPRESSION BRAIN PHOSPHORYLATION TUMORIGENESIS MIR-17-92 CANCER |
| 通讯作者 | Zhou, WH (reprint author), Fudan Univ, Dept Neonatol, Childrens Hosp, Shanghai 201102, Peoples R China. ; Zhou, WH (reprint author), Fudan Univ, Childrens Hosp, Key Lab Birth Defects, Shanghai 201102, Peoples R China.,zwhchfu@126.com |
| 英文摘要 | MeCP2 encodes a methyl-CpG-binding protein that plays a critical role in repressing gene expression, mutations of which lead to Rett syndrome and autism. PTEN is a critical tumor suppressor gene that is frequently mutated in human cancers and autism spectrum disorders. Various studies have shown that both MeCP2 and PTEN proteins play important roles in brain development. Here we find that MeCP2 and PTEN reciprocally regulate expression of each other via microRNAs. Knockdown of MeCP2 leads to upregulation of microRNA-137, which in turn represses expression of PTEN, thus PTEN would be down-regulated when MeCP2 is knockdown. Furthermore, we find that deletion of PTEN leads to phosphorylation of Serine 133 of CREB, then increases the expression of microRNA-132. miR-132 inhibits the expression of MeCP2 by targeting on the 3'UTR of MeCP2 mRNA. Our work shows that two critical disorders-related gene MeCP2 and PTEN reciprocally regulate expression of each other by distinct mechanisms, suggesting that rare mutations in various disorders may lead to dysregulation of other critical genes and yield unexpected consequences. |
| WOS标题词 | Science & Technology - Other Topics |
| 学科主题 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000369277000001 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4040]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Lyu, JW,Yuan, B,Cheng, TL,et al. Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs[J]. SCIENTIFIC REPORTS,2016,6:20392. |
| APA | Lyu, JW,Yuan, B,Cheng, TL,Qiu, ZL,&Zhou, WH.(2016).Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs.SCIENTIFIC REPORTS,6,20392. |
| MLA | Lyu, JW,et al."Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs".SCIENTIFIC REPORTS 6(2016):20392. |
入库方式： OAI收割
来源：上海神经科学研究所
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