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Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection
文献类型：期刊论文
| 作者 | Yao, YY; Li, XQ; Zhang, BB; Yin, C; Liu, YF; Chen, WY; Zeng, SQ; Du, JL |
| 刊名 | NEURON
 |
| 出版日期 | 2016 |
| 卷号 | 89期号:3页码:598-612 |
| 关键词 | VENTRAL TEGMENTAL AREA DECISION-MAKING MAUTHNER CELL SENSORIMOTOR TRANSFORMATION NEURONAL CIRCUITS OBJECT APPROACH GABA NEURONS ZEBRAFISH ACTIVATION HINDBRAIN |
| 通讯作者 | Du, JL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Inst Neurosci,State Key Lab Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China. ; Du, JL (reprint author), Univ Chinese Acad Sci, Grad Sch, 320 Yue Yang Rd, Shanghai 200031, Peoples R China. ; Du, JL (reprint author), ShanghaiTech Univ, Sch Life Sci & Technol, 319 Yue Yang Rd, Shanghai 200031, Peoples R China.,forestdu@ion.ac.cn |
| 英文摘要 | Animals behave differently in response to visual cues with distinct ethological meaning, a process usually thought to be achieved through differential visual processing. Using a defined zebrafish escape circuit as a model, we found that behavior selection can be implemented at the visuomotor transformation stage through a visually responsive dopaminergic-inhibitory circuit module. In response to non-threatening visual stimuli, hypothalamic dopaminergic neurons and their positively regulated hindbrain inhibitory interneurons increase activity, suppressing synaptic transmission from the visual center to the escape circuit. By contrast, threatening visual stimuli inactivate some of these neurons, resulting in dis-inhibition of the visuomotor transformation and escape generation. The distinct patterns of dopaminergic-inhibitory neural module's visual responses account for this stimulus-specific visuomotor transformation and behavioral control. Thus, our study identifies a behavioral relevance-dependent mechanism that controls visuomotor transformation and behavior selection and reveals that neuromodulation can be tuned by visual cues to help animals generate appropriate responses. |
| 学科主题 | Neurosciences |
| WOS标题词 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000373564900017 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4041]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Yao, YY,Li, XQ,Zhang, BB,et al. Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection[J]. NEURON,2016,89(3):598-612. |
| APA | Yao, YY.,Li, XQ.,Zhang, BB.,Yin, C.,Liu, YF.,...&Du, JL.(2016).Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection.NEURON,89(3),598-612. |
| MLA | Yao, YY,et al."Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection".NEURON 89.3(2016):598-612. |
入库方式： OAI收割
来源：上海神经科学研究所
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