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Actin Aggregations Mark the Sites of Neurite Initiation
文献类型：期刊论文
| 作者 | Zhang, SX; Duan, LH; Qian, H; Yu, X |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2016 |
| 卷号 | 32期号:1页码:1-15 |
| 关键词 | NEURONAL POLARITY MOLECULAR-MECHANISMS IN-VIVO DENDRITIC ARBORIZATION ENA/VASP PROTEINS 3-KINASE ACTIVITY CELL BIOLOGY MICROTUBULES POLARIZATION FILOPODIA |
| 通讯作者 | Yu, X (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, State Key Lab Neurosci,Inst Neurosci, Shanghai 200031, Peoples R China.,yuxiang@ion.ac.cn |
| 英文摘要 | A salient feature of neurons is their intrinsic ability to grow and extend neurites, even in the absence of external cues. Compared to the later stages of neuronal development, such as neuronal polarization and dendrite morphogenesis, the early steps of neuritogenesis remain relatively unexplored. Here we showed that redistribution of cortical actin into large aggregates preceded neuritogenesis and determined the site of neurite initiation. Enhancing actin polymerization by jasplakinolide treatment effectively blocked actin redistribution and neurite initiation, while treatment with the actin depolymerizing agents latrunculin A or cytochalasin D accelerated neurite formation. Together, these results demonstrate a critical role of actin dynamics and reorganization in neurite initiation. Further experiments showed that microtubule dynamics and protein synthesis are not required for neurite initiation, but are required for later neurite stabilization. The redistribution of actin during early neuronal development was also observed in the cerebral cortex and hippocampus in vivo. |
| 学科主题 | Neurosciences |
| WOS标题词 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000369430500001 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4043]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, SX,Duan, LH,Qian, H,et al. Actin Aggregations Mark the Sites of Neurite Initiation[J]. NEUROSCIENCE BULLETIN,2016,32(1):1-15. |
| APA | Zhang, SX,Duan, LH,Qian, H,&Yu, X.(2016).Actin Aggregations Mark the Sites of Neurite Initiation.NEUROSCIENCE BULLETIN,32(1),1-15. |
| MLA | Zhang, SX,et al."Actin Aggregations Mark the Sites of Neurite Initiation".NEUROSCIENCE BULLETIN 32.1(2016):1-15. |
入库方式： OAI收割
来源：上海神经科学研究所
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