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Endocardium Contributes to Cardiac Fat
文献类型：期刊论文
| 作者 | Zhang, H; Pu, WJ; Liu, QZ; He, LJ; Huang, XZ; Tian, XY; Zhang, LB; Nie, Y; Hu, SS; Lui, KO |
| 刊名 | CIRCULATION RESEARCH
 |
| 出版日期 | 2016 |
| 卷号 | 118期号:2页码:254-265 |
| 关键词 | MESENCHYMAL TRANSITION CORONARY-ARTERIES MYOCARDIAL-INFARCTION ADIPOSE-TISSUE HEART FIELD CELLS ANGIOGENESIS CRE LINEAGE FORM |
| 通讯作者 | Zhou, B (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Key Lab Nutr & Metab,Inst Nutr Sci, Shanghai 200031, Peoples R China.,zhoubin@sibs.ac.cn |
| 英文摘要 | Rationale: Unraveling the developmental origin of cardiac fat could offer important implications for the treatment of cardiovascular disease. The recent identification of the mesothelial source of epicardial fat tissues reveals a heterogeneous origin of adipocytes in the adult heart. However, the developmental origin of adipocytes inside the heart, namely intramyocardial adipocytes, remains largely unknown. Objective: To trace the developmental origin of intramyocardial adipocytes. Methods and Results: In this study, we identified that the majority of intramyocardial adipocytes were restricted to myocardial regions in close proximity to the endocardium. Using a genetic lineage tracing model of endocardial cells, we found that Nfatc1(+) endocardial cells contributed to a substantial number of intramyocardial adipocytes. Despite the capability of the endocardium to generate coronary vascular endothelial cells surrounding the intramyocardial adipocytes, results from our lineage tracing analyses showed that intramyocardial adipocytes were not derived from coronary vessels. Nevertheless, the endocardium of the postnatal heart did not contribute to intramyocardial adipocytes during homeostasis or after myocardial infarction. Conclusions: Our in vivo fate-mapping studies demonstrated that the developing endocardium, but not the vascular endothelial cells, gives rise to intramyocardial adipocytes in the adult heart. |
| 学科主题 | Cardiac & Cardiovascular Systems; Hematology; Peripheral Vascular Disease |
| WOS标题词 | Cardiovascular System & Cardiology ; Hematology |
| 语种 | 英语 |
| WOS记录号 | WOS:000368729100012 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4044]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Zhang, H,Pu, WJ,Liu, QZ,et al. Endocardium Contributes to Cardiac Fat[J]. CIRCULATION RESEARCH,2016,118(2):254-265. |
| APA | Zhang, H.,Pu, WJ.,Liu, QZ.,He, LJ.,Huang, XZ.,...&Zhou, B.(2016).Endocardium Contributes to Cardiac Fat.CIRCULATION RESEARCH,118(2),254-265. |
| MLA | Zhang, H,et al."Endocardium Contributes to Cardiac Fat".CIRCULATION RESEARCH 118.2(2016):254-265. |
入库方式： OAI收割
来源：上海神经科学研究所
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