中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
A Phenomenological Synapse Model for Asynchronous Neurotransmitter Release

文献类型:期刊论文

作者Wang, T; Yin, LP; Zou, XL; Shu, YS; Rasch, MJ; Wu, S
刊名FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
出版日期2016
卷号9页码:153
关键词TRANSMITTER RELEASE GABA RELEASE SYNAPTOTAGMIN-1 MICROCIRCUITS INHIBITION PLASTICITY NEURONS
通讯作者Rasch, MJ (reprint author), Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China.,malte.rasch@bnu.edu.cn ; wusi@bnu.edu.cn
英文摘要Neurons communicate with each other via synapses. Action potentials cause release of neurotransmitters at the axon terminal. Typically, this neurotransmitter release is tightly time-locked to the arrival of an action potential and is thus called synchronous release. However, neurotransmitter release is stochastic and the rate of release of small quanta of neurotransmitters can be considerably elevated even long after the ceasing of spiking activity, leading to asynchronous release of neurotransmitters. Such asynchronous release varies for tissue and neuron types and has been shown recently to be pronounced in fast-spiking neurons. Notably, it was found that asynchronous release is enhanced in human epileptic tissue implicating a possibly important role in generating abnormal neural activity. Current neural network models for simulating and studying neural activity virtually only consider synchronous release and ignore asynchronous transmitter release. Here, we develop a phenomenological model for asynchronous neurotransmitter release, which, on one hand, captures the fundamental features of the asynchronous release process, and, on the other hand, is simple enough to be incorporated in large-size network simulations. Our proposed model is based on the well-known equations for short-term dynamical synaptic interactions and includes an additional stochastic term for modeling asynchronous release. We use experimental data obtained from inhibitory fast-spiking synapses of human epileptic tissue to fit the model parameters, and demonstrate that our model reproduces the characteristics of realistic asynchronous transmitter release.
学科主题Mathematical & Computational Biology; Neurosciences
WOS标题词Mathematical & Computational Biology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000368406800001
源URL[http://ir.sibs.ac.cn/handle/331001/4046]  
专题上海神经科学研究所_神经所(总)
推荐引用方式
GB/T 7714
Wang, T,Yin, LP,Zou, XL,et al. A Phenomenological Synapse Model for Asynchronous Neurotransmitter Release[J]. FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,2016,9:153.
APA Wang, T,Yin, LP,Zou, XL,Shu, YS,Rasch, MJ,&Wu, S.(2016).A Phenomenological Synapse Model for Asynchronous Neurotransmitter Release.FRONTIERS IN COMPUTATIONAL NEUROSCIENCE,9,153.
MLA Wang, T,et al."A Phenomenological Synapse Model for Asynchronous Neurotransmitter Release".FRONTIERS IN COMPUTATIONAL NEUROSCIENCE 9(2016):153.

入库方式: OAI收割

来源:上海神经科学研究所

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