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beta-Arrestin1 regulates the morphology and dynamics of microglia in zebrafish in vivo
文献类型：期刊论文
| 作者 | Li, YY; Du, XF; Pei, G; Du, JL; Zhao, J |
| 刊名 | EUROPEAN JOURNAL OF NEUROSCIENCE
 |
| 出版日期 | 2016 |
| 卷号 | 43期号:2页码:131-138 |
| 关键词 | ALZHEIMERS-DISEASE PATHOGENESIS PROTEASE-ACTIVATED RECEPTOR-2 BREAST-CANCER CELLS RESTING MICROGLIA BETA-ARRESTINS BRAIN PHOSPHORYLATION MOTILITY DOWNSTREAM MIGRATION |
| 通讯作者 | Zhao, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, State Key Lab Cell Biol,Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,jzhao@sibcb.ac.cn |
| 英文摘要 | Microglia are the primary immune cells in the central nervous system. Microglia typically exist in a 'resting' state in the healthy brain, with ramified processes dynamically exploring the surrounding microenvironment. They become 'activated' under pathological conditions with marked changes in morphology. However, the regulation of their morphology dynamics remains poorly understood. Here, using in vivo time-lapse imaging and three-dimensional morphology analysis of microglia in intact zebrafish larvae, we found that beta-arrestin1, a multifunctional protein involved in various signal transductions, cell-autonomously regulated the microglial morphology. Knockdown of beta-arrestin1 increased the volume size and process number of microglia but reduced the deformation speed in the resting state. Meanwhile, beta-arrestin1 down-regulation led to a high frequency of phagocytic behaviour of microglia. These defects were partially rescued by over-expressing human beta-arrestin1 in microglia. Our study indicated that microglial dynamics in the resting state can be regulated cell-autonomously by beta-arrestin1 signalling. |
| 学科主题 | Neurosciences |
| WOS标题词 | Neurosciences & Neurology |
| 语种 | 英语 |
| WOS记录号 | WOS:000368245600001 |
| 源URL | [http://ir.sibs.ac.cn/handle/331001/4048]  |
| 专题 | 上海神经科学研究所_神经所(总) |
| 推荐引用方式 GB/T 7714 | Li, YY,Du, XF,Pei, G,et al. beta-Arrestin1 regulates the morphology and dynamics of microglia in zebrafish in vivo[J]. EUROPEAN JOURNAL OF NEUROSCIENCE,2016,43(2):131-138. |
| APA | Li, YY,Du, XF,Pei, G,Du, JL,&Zhao, J.(2016).beta-Arrestin1 regulates the morphology and dynamics of microglia in zebrafish in vivo.EUROPEAN JOURNAL OF NEUROSCIENCE,43(2),131-138. |
| MLA | Li, YY,et al."beta-Arrestin1 regulates the morphology and dynamics of microglia in zebrafish in vivo".EUROPEAN JOURNAL OF NEUROSCIENCE 43.2(2016):131-138. |
入库方式： OAI收割
来源：上海神经科学研究所
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