Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin
文献类型：期刊论文
| 作者 | Wang, Teng1,2; Xie, Xi-xiu1; Ji, Mei1; Wang, Shao-wei1; Zha, Jun1; Zhou, Wei-wei1; Yu, Xiao-lin1; Wei, Chen4; Ma, Shan3; Xi, Zhi-ying3 |
| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 105期号:JUNE页码:561-576 |
| 关键词 | Alzheimer's disease beta-amyloid Intravenous immunoglobulin Oligomers Antibody |
| ISSN号 | 0028-3908 |
| 英文摘要 | Alzheimer's disease (AD) is characterized by memory loss, intracellular neurofibrillary tangles, and extracellular plaque deposits composed of beta-amyloid (A beta). Previous reports showed that naturally occurring autoantibodies, such as intravenous immunoglobulin (IVIG), benefited patients with moderate-stage AD who carried an APOE-epsilon 4 allele. However, the mechanism underlying the role of IVIG remains unclear. In this study, we identified naturally occurring autoantibodies against A beta oligomers (NAbs-A beta o), which were purified by A beta 42 oligomer or Cibacron Blue affinity chromatography from IVIG and termed as Oli-NAbs and Blue-NAbs, respectively. Oli-NAbs and Blue-NAbs recognized A beta 42 oligomers or both A beta 40 and 42 oligomers, differently. Both antibodies inhibited A beta 42 aggregation and attenuated A beta 42-induced cytotoxicity. Compared with vehicles, Oli-NAbs, Blue-NAbs and IVIG significantly improved the memory and cognition, and reduced the soluble and oligomeric A beta levels in APPswe/PS1dE9 transgenic mice. Further investigation showed that Blue-NAbs at increased doses effectively decreased plaque burden and insoluble A beta levels, whereas Oli-NAbs significantly declined the microgliosis and astrogliosis, as well as the production of proinflammatory cytokines in vivo. Therefore, high levels of these antibodies against oligomeric A beta 40 or A beta 42 were required, correspondingly, to achieve the optimal effect. NAbs-A beta o could be condensed to a high concentration by affinity chromatography and its isolation from IVIG may not interfere with the normal function of conventional IVIG as its concentration is very low. Thus, the isolated NAbs-A beta o as an extra product of plasma required low cost and the enriched NAbs-A beta o may be more feasible than IVIG for the treatment of AD. (C) 2016 Elsevier Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Neurosciences ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 关键词[WOS] | AMYLOID-BETA ; MEMORY DEFICITS ; ANTIBODIES ; IMMUNOTHERAPY ; IMMUNIZATION ; PROTEIN ; MICROGLIA ; PEPTIDE ; TRIALS ; MICE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377311300053 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/20955]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.AnHui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China 3.Shandong Inst Biol Prod, Tai An 2710000, Shandong, Peoples R China 4.Natl Inst Food & Drug Control, Beijing 100050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Teng,Xie, Xi-xiu,Ji, Mei,et al. Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin[J]. NEUROPHARMACOLOGY,2016,105(JUNE):561-576. |
| APA | Wang, Teng.,Xie, Xi-xiu.,Ji, Mei.,Wang, Shao-wei.,Zha, Jun.,...&Liu, Rui-tian.(2016).Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin.NEUROPHARMACOLOGY,105(JUNE),561-576. |
| MLA | Wang, Teng,et al."Naturally occurring autoantibodies against A beta oligomers exhibited more beneficial effects in the treatment of mouse model of Alzheimer's disease than intravenous immunoglobulin".NEUROPHARMACOLOGY 105.JUNE(2016):561-576. |
入库方式： OAI收割
来源：过程工程研究所
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