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Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV

文献类型：期刊论文

作者Dong, Yaqiong1,2; Yang, Jun1; Zhang, Jinchao2; Zhang, Xin1
刊名JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
出版日期2016-03-01
卷号16期号:3页码:2126-2133
关键词HIV DNA Vaccine Immunogenicity Nano-Delivery Vehicles Adjuvants
ISSN号1533-4880
英文摘要More than 75 million people has been infected HIV and it is responsible for nearly 36 million deaths on a global scale. As one of the deadliest infectious diseases, HIV is becoming the urgent issue of the global epidemic to tackle. In order to settle this problem from the source, some effective prevention strategies should be developed to control the pandemic of HIV. Vaccines, especially DNA vaccines, could be the optimal way to control the spread of HIV due to the unparalleled superiority that DNA vaccines could generate long-term humoral and cellular immune responses which could provide protective immunity for HIV. But the naked DNA could hardly enter into cells and is easily degraded by DNases and lysosomes, so designing effective delivery system is a promising strategy. Since delivery system could be constructed to promote efficient delivery of DNA into mammalian cells, protect them from degradation, and also could be established to be a target system to arrive at certain position of expectation. The current review discusses the potential of various nano-delivery vehicles/adjuvants such as polymer, lipid, liposome, peptide and inorganic material in improving efficiency of diverse modalities available for HIV DNA vaccines.
WOS标题词Science & Technology ; Physical Sciences ; Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]IMMUNODEFICIENCY-VIRUS TYPE-1 ; MEDIATED IMMUNE-RESPONSES ; MONOPHOSPHORYL-LIPID-A ; HEPATITIS-B-VACCINE ; GENE DELIVERY ; CHITOSAN NANOPARTICLES ; CONTROLLED-RELEASE ; PEI/DNA COMPLEXES ; DRUG-DELIVERY ; PEPTIDE
收录类别SCI
语种英语
WOS记录号WOS:000374153800003
源URL[http://ir.ipe.ac.cn/handle/122111/21010]  
专题过程工程研究所_生化工程国家重点实验室
作者单位1.Chinese Acad Sci, Natl Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Chem Biol Key Lab Hebei Prov, Key Lab Med Chem & Mol Diag,Minist Educ, Baoding 071002, Peoples R China
推荐引用方式
GB/T 7714		 Dong, Yaqiong,Yang, Jun,Zhang, Jinchao,et al. Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2016,16(3):2126-2133.
APA Dong, Yaqiong,Yang, Jun,Zhang, Jinchao,&Zhang, Xin.(2016).Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,16(3),2126-2133.
MLA Dong, Yaqiong,et al."Nano-Delivery Vehicles/Adjuvants for DNA Vaccination Against HIV".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 16.3(2016):2126-2133.

入库方式： OAI收割

来源：过程工程研究所

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