A Novel Multifunctional Compound Camellikaempferoside B Decreases A beta Production, Interferes with A beta Aggregation, and Prohibits A beta-Mediated Neurotoxicity and Neuroinflammation
文献类型：期刊论文
| 作者 | Yang, Shigao1; Liu, Wen1,3; Lu, Shuai1; Tian, Yong-zhen2; Wang, Wei-yun3; Ling, Tie-jun2; Liu, Rui-tian1 |
| 刊名 | ACS CHEMICAL NEUROSCIENCE
 |
| 出版日期 | 2016-04-01 |
| 卷号 | 7期号:4页码:505-518 |
| 关键词 | Amyloid-beta camellikaempferoside B beta-secretase aggregation neurotoxicity microglia |
| ISSN号 | 1948-7193 |
| 英文摘要 | Accumulating evidence suggested that soluble oligomeric beta-amyloid protein (A beta) exerts diverse roles in neuronal cell death, neuroinflammation, oxidative stress, and the eventual dementia associated with Alzheimer's disease (AD). Developing an agent with multiple properties may be a reasonable strategy for the treatment of AD. In this study, we isolated a novel multifunctional compound named camellikaempferoside B (YCF-2) from Fuzhuan brick tea. YCF-2 consists of kaempferol backbone, p-coumaric acid (p-CA) group, and a novel structure of rhamnopyranosyl group at the C-4' position, possessing the properties of both kaempferol and p-CA. YCF-2 significantly inhibited A beta production by decreasing beta-secretase activity. Moreover, YCF-2 suppressed A beta 42 fibrillation and facilitated nontoxic oligomer formation by binding to A beta 42 oligomers and by blocking the conformational transition to beta-sheet. Furthermore, YCF-2 ameliorated A beta-induced neuronal cell death, ROS production, inflammatory factor release, and microglia activation by blocking the NF-kappa B signaling pathway in microglia. These findings indicated that YCF-2 with a novel lead structure has potential applications for drug development for AD treatment. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Neurosciences |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Neurosciences & Neurology |
| 关键词[WOS] | NF-KAPPA-B ; AMYLOID PRECURSOR PROTEIN ; DISEASE TRANSGENIC MICE ; RESCUES MEMORY DEFICITS ; P-COUMARIC ACID ; ALZHEIMERS-DISEASE ; OXIDATIVE STRESS ; NEURONAL APOPTOSIS ; QUERCETIN PROTECTS ; FIBRIL FORMATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000374812300013 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21032]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, 130 West Changjiang Rd, Hefei 230036, Peoples R China 3.Anhui Agr Univ, Sch Life Sci, Hefei 230036, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Shigao,Liu, Wen,Lu, Shuai,et al. A Novel Multifunctional Compound Camellikaempferoside B Decreases A beta Production, Interferes with A beta Aggregation, and Prohibits A beta-Mediated Neurotoxicity and Neuroinflammation[J]. ACS CHEMICAL NEUROSCIENCE,2016,7(4):505-518. |
| APA | Yang, Shigao.,Liu, Wen.,Lu, Shuai.,Tian, Yong-zhen.,Wang, Wei-yun.,...&Liu, Rui-tian.(2016).A Novel Multifunctional Compound Camellikaempferoside B Decreases A beta Production, Interferes with A beta Aggregation, and Prohibits A beta-Mediated Neurotoxicity and Neuroinflammation.ACS CHEMICAL NEUROSCIENCE,7(4),505-518. |
| MLA | Yang, Shigao,et al."A Novel Multifunctional Compound Camellikaempferoside B Decreases A beta Production, Interferes with A beta Aggregation, and Prohibits A beta-Mediated Neurotoxicity and Neuroinflammation".ACS CHEMICAL NEUROSCIENCE 7.4(2016):505-518. |
入库方式： OAI收割
来源：过程工程研究所
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