Revealing the role of oxidation state in interaction between nitro/amino-derived particulate matter and blood proteins
文献类型：期刊论文
| 作者 | Liu, Zhen1; Li, Ping2,3; Bian, Weiwei4; Yu, Jingkai2; Zhan, Jinhua1 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-05-16 |
| 卷号 | 6期号:MAY页码:25909 |
| ISSN号 | 2045-2322 |
| 英文摘要 | Surface oxidation states of ultrafine particulate matter can influence the proinflammatory responses and reactive oxygen species levels in tissue. Surface active species of vehicle-emission soot can serve as electron transfer-mediators in mitochondrion. Revealing the role of surface oxidation state in particles-proteins interaction will promote the understanding on metabolism and toxicity. Here, the surface oxidation state was modeled by nitro/amino ligands on nanoparticles, the interaction with blood proteins were evaluated by capillary electrophoresis quantitatively. The nitro shown larger affinity than amino. On the other hand, the affinity to hemoglobin is 103 times larger than that to BSA. Further, molecular docking indicated the difference of binding intensity were mainly determined by hydrophobic forces and hydrogen bonds. These will deepen the quantitative understanding of protein-nanoparticles interaction from the perspective of surface chemical state. |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | BOVINE SERUM-ALBUMIN ; ENHANCED RAMAN-SCATTERING ; ESTERASE-LIKE ACTIVITY ; CRYSTALLOGRAPHIC ANALYSIS ; NITROPHENYL ESTERS ; FREE-RADICALS ; NANOPARTICLES ; POLLUTION ; BINDING ; SURFACE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375919200002 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21051]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Shandong Univ, Minist Educ, Dept Chem, Key Lab Colloid & Interface Chem, Jinan 250100, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Weifang Med Univ, Dept Pharm, Weifang 261053, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhen,Li, Ping,Bian, Weiwei,et al. Revealing the role of oxidation state in interaction between nitro/amino-derived particulate matter and blood proteins[J]. SCIENTIFIC REPORTS,2016,6(MAY):25909. |
| APA | Liu, Zhen,Li, Ping,Bian, Weiwei,Yu, Jingkai,&Zhan, Jinhua.(2016).Revealing the role of oxidation state in interaction between nitro/amino-derived particulate matter and blood proteins.SCIENTIFIC REPORTS,6(MAY),25909. |
| MLA | Liu, Zhen,et al."Revealing the role of oxidation state in interaction between nitro/amino-derived particulate matter and blood proteins".SCIENTIFIC REPORTS 6.MAY(2016):25909. |
入库方式： OAI收割
来源：过程工程研究所
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