Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies
文献类型：期刊论文
| 作者 | Fan, Qingze1,2; Qi, Feng1,2; Miao, Chunyu1,3; Yue, Hua1,3; Gong, Fangling1,3; Wu, Jie1,3; Ma, Guanghui1,3; Su, Zhiguo1,3 |
| 刊名 | COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
 |
| 出版日期 | 2016-07-05 |
| 卷号 | 500期号:AUG页码:177-185 |
| 关键词 | Non-spherical particles Uniform size Deformation Premix membrane emulsification technique Drug delivery system |
| ISSN号 | 0927-7757 |
| 英文摘要 | Biodegradable polymeric particles have been widely used in the biomedical fields such as drug carriers, tissue engineering, and medical imaging. It has been recognized that the physical properties of particles, such as size and shape, have a profound influence on their functions. However, it is not easy to prepare non-spherical particles by the conventional emulsion-based method because the minimization of interfacial energy leads to the spontaneous formation of spherical emulsions and it is difficult to control the uniformity and size. In order to solve this problem, we developed a direct method to fabricate non spherical polylactic-co-glycolic acid (PLGA) particles with uniform size. This method employed a common agent, phosphate buffer saline (PBS), as the deformation initiator and combined the premix membrane emulsification technique with the solvent evaporation method to prepare uniform non-spherical particles of various shapes with aspect ratios from 2 to 40 and various sizes ranging from 800 nm to 60 pin (long axis). We found that the external driving force of stirring and the interfacial tension of the droplet dictated by the constitution of PBS and polyvinyl alcohol (PVA) have synergistic effects on the deformation. Through confocal laser microscopy (CLSM), the deforming process was observed visually in the solvent and gel state during the solidification. Moreover, octreotide acetate as a model peptide was successfully encapsulated into the non-spherical particles. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Physical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | DRUG-DELIVERY ; POLYMERIC NANOPARTICLES ; MICROSPHERES ; MICROPARTICLES ; MONODISPERSE ; FABRICATION ; BIODISTRIBUTION ; MICROFLUIDICS ; PHAGOCYTOSIS ; SIZE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000375860100021 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21052]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fan, Qingze,Qi, Feng,Miao, Chunyu,et al. Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2016,500(AUG):177-185. |
| APA | Fan, Qingze.,Qi, Feng.,Miao, Chunyu.,Yue, Hua.,Gong, Fangling.,...&Su, Zhiguo.(2016).Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,500(AUG),177-185. |
| MLA | Fan, Qingze,et al."Direct and controllable preparation of uniform PLGA particles with various shapes and surface morphologies".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 500.AUG(2016):177-185. |
入库方式： OAI收割
来源：过程工程研究所
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