Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles
文献类型：期刊论文
| 作者 | Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Ma, Kai2,3; Ma, Guanghui3; Moehwald, Helmuth4; Yan, Xuehai3 |
| 刊名 | SCIENTIFIC REPORTS
 |
| 出版日期 | 2016-05-23 |
| 卷号 | 6期号:MAY页码:26506 |
| ISSN号 | 2045-2322 |
| 英文摘要 | The design of advanced, nanostructured materials by layer-by-layer (LbL) assembly at the molecular level is of great interest because of the broad application of these materials in the biomedical field especially in regulating cell growth, adhesion, movement, differentiation and detachment. Here, we fabricated functional hybrid multilayer films by LbL assembly of biocompatible photosensitizer-coupled polypeptides and collagen-capped gold nanoparticles. The resulting multilayer film can well accommodate cells for adhesion, growth and proliferation. Most significantly, controlled cell apoptosis (detachment) and patterning of the multilayer film is achieved by a photochemical process yielding reactive oxygen species (ROS). Moreover, the site and shape of apoptotic cells can be controlled easily by adjusting the location and shape of the laser beam. The LbL assembled multilayer film with integration of functions provides an efficient platform for regulating cell growth and apoptosis (detachment). |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Multidisciplinary Sciences |
| 研究领域[WOS] | Science & Technology - Other Topics |
| 关键词[WOS] | MECHANICAL-PROPERTIES ; SURFACES ; FILMS ; POLYELECTROLYTE ; DETACHMENT ; ADHESION ; SYSTEMS ; GROWTH ; TRANSFECTION ; NANOTUBES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000376357000001 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21084]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China 2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Max Planck Inst Colloids & Interfaces, Muhlenberg 1, D-14476 Potsdam, Germany |
| 推荐引用方式 GB/T 7714 | Xing, Ruirui,Jiao, Tifeng,Ma, Kai,et al. Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles[J]. SCIENTIFIC REPORTS,2016,6(MAY):26506. |
| APA | Xing, Ruirui,Jiao, Tifeng,Ma, Kai,Ma, Guanghui,Moehwald, Helmuth,&Yan, Xuehai.(2016).Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles.SCIENTIFIC REPORTS,6(MAY),26506. |
| MLA | Xing, Ruirui,et al."Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles".SCIENTIFIC REPORTS 6.MAY(2016):26506. |
入库方式： OAI收割
来源：过程工程研究所
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