Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy
文献类型：期刊论文
| 作者 | Zhang, Ruiyun1,2; Xing, Ruirui1,2,3; Jiao, Tifeng1,2; Ma, Kai1,2; Chen, Chengjun3,4; Ma, Guanghui3; Yan, Xuehai3,4 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 8期号:21页码:13262-13269 |
| 关键词 | nanodrugs self-assembly codelivery photodynamic therapy antitumor therapy |
| ISSN号 | 1944-8244 |
| 英文摘要 | There are tremendous challenges from both tumor and its therapeutic formulations affecting the effective treatment of tumor, including tumor recurrence, and complex multistep preparations of formulation. To address these issues, herein a simple and green approach based on the self-assembly of therapeutic agents including a photosensitizer (chlorine e6, Ce6) and a chemotherapeutic agent (doxorubicin, DOX) was developed to prepare carrier free nanoparticles (NPs) with the ability to inhibit tumor recurrence. The designed NPs were formed by self-assembly of Ce6 and DOX associated with electrostatic, pi-pi stacking and hydrophobic interactions. They have a relatively uniform size of average 70 nm, surface charge of -20 mV and high drug encapsulation efficiency, which benefits the favorable accumulation of drugs at the tumor region through a potential enhanced permeability and retention (EPR) effect as compared to their counterpart of free Ce6 solution. In addition, they could eradiate tumors without recurrence in a synergistic way following one treatment cycle. Furthermore, the NPs are safe without any activation of inflammation or immune response in separated organs. Taken together, the rationale of these pure nanodrugs via the self-assembly approach might open an alternative avenue and give inspiration to fabricate new carrier-free nanodrugs for tumor theranostics, especially for two small molecular antitumor drugs with the aim of combinational antitumor therapy in a synergistic way. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | OVERCOMING DRUG-RESISTANCE ; PHOTODYNAMIC THERAPY ; CANCER-THERAPY ; BIOMEDICAL APPLICATIONS ; MULTIDRUG-RESISTANCE ; SIRNA DELIVERY ; IN-VITRO ; NANOPARTICLES ; PROTEIN ; COMBINATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000377150400010 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21155]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Yanshan Univ, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China 2.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, Qinhuangdao 066004, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Ruiyun,Xing, Ruirui,Jiao, Tifeng,et al. Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2016,8(21):13262-13269. |
| APA | Zhang, Ruiyun.,Xing, Ruirui.,Jiao, Tifeng.,Ma, Kai.,Chen, Chengjun.,...&Yan, Xuehai.(2016).Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy.ACS APPLIED MATERIALS & INTERFACES,8(21),13262-13269. |
| MLA | Zhang, Ruiyun,et al."Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy".ACS APPLIED MATERIALS & INTERFACES 8.21(2016):13262-13269. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。