Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy
文献类型：期刊论文
| 作者 | Shen, Guizhi1,2; Xing, Ruirui1,2; Zhang, Ning1; Chen, Chengjun1; Ma, Guanghui1; Yan, Xuehai1,2 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2016-06-01 |
| 卷号 | 10期号:6页码:5720-5729 |
| 关键词 | hydrophobic drugs nanoengineering interfacial assembly Ostwald ripening suppression drug delivery |
| ISSN号 | 1936-0851 |
| 英文摘要 | The majority of anticancer drugs are poorly water-soluble and thus suffer from rather low bioavailability. Although a variety of delivery carriers have been developed for bioavailability improvement, they are severely limited by low drug loading and undesired side effects. The optimum delivery vehicle would be a biocompatible and biodegradable drug nanoparticle of uniform size with a thin but stable shell, making it soluble, preventing aggregation and enabling targeting. Here, we present a general strategy for the rational design of hydrophobic drug nanoparticles with high drug loading by means of interfacial cohesion and supramolecular assembly of bioadhesive species. We demonstrate that the pathway is capable of effectively suppressing and retarding Ostwald ripening, providing drug nanoparticles with small and uniform size and long-term colloidal stability. The final complex drug nanoparticles provide higher tumor accumulation, negligible toxicity, and enhanced antitumor activity, superior to commercial formulations. Our findings demonstrate that local, on-demand coating of hydrophobic nanoparticles is achievable through cooperation and compromise of interfacial adhesion and assembly. |
| WOS标题词 | Science & Technology ; Physical Sciences ; Technology |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| 研究领域[WOS] | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 关键词[WOS] | DRUG-DELIVERY ; CANCER-THERAPY ; POLYMERIC MICELLES ; TANNIC-ACID ; NANOPARTICLES ; NANOMEDICINE ; CAPSULES ; SIZE ; IRON ; NANOARCHITECTONICS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000378973700015 |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/21170]  |
| 专题 | 过程工程研究所_生化工程国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Ctr Mesosci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, Guizhi,Xing, Ruirui,Zhang, Ning,et al. Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy[J]. ACS NANO,2016,10(6):5720-5729. |
| APA | Shen, Guizhi,Xing, Ruirui,Zhang, Ning,Chen, Chengjun,Ma, Guanghui,&Yan, Xuehai.(2016).Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy.ACS NANO,10(6),5720-5729. |
| MLA | Shen, Guizhi,et al."Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy".ACS NANO 10.6(2016):5720-5729. |
入库方式： OAI收割
来源：过程工程研究所
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