New Tanshinone IIA Delivery System Using Chitosan Nanomicelles of Small Size
文献类型：期刊论文
| 作者 | Li Hong1,3; Du Libo1; Zhang Han1; Zhao Yuming2; Liu Yang1,3 |
| 刊名 | CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
 |
| 出版日期 | 2016-07-10 |
| 卷号 | 37期号:7页码:1229-1231 |
| 关键词 | Chitosan nanomicelles of small size Tanshinone IIA Neuroprotectant Delivery for poorly soluble drugs |
| 英文摘要 | It is still a great challenge to design and synthesize ultra. small chitosan nanoparticles for encapsulating highly hydrophobic neuroprotectants, such as anti. stroke drug tanshinone IIA. To address the issue, a new amphiphilic polymeric micelle system (i.e. CS-g-TPS) was synthesized by covalent linking of D-alpha-tocopherol succinic acid ester with hydroxylethyl. chitosan in a green and effective approach. The results showed that the obtained CS-g-TPS can be self. assembled into ultra. small nanoparticles by hydrophilic. hydrophobic interaction in aqueous solution, which can be effectively loaded with tanshinone IIA. The particle size and morphology were characterized by scanning electron microscopy(SEM) and dynamic light scattering (DLS), respectively. Bioassays of cell viability and drug uptake further revealed that the CS-g-TPS/tanshinone IIA delivery system could achieve excellent in vitro biocompatibility, as well as high cellular uptake efficiency. It indicated that CS-g-TPS might be a promising drug delivery system for water insoluble neuroprotectant with the characteristics of high biosafety. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35192]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 2.Capital Med Univ, Sch Basic Med Sci, Beijing 100069, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Hong,Du Libo,Zhang Han,et al. New Tanshinone IIA Delivery System Using Chitosan Nanomicelles of Small Size[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2016,37(7):1229-1231. |
| APA | Li Hong,Du Libo,Zhang Han,Zhao Yuming,&Liu Yang.(2016).New Tanshinone IIA Delivery System Using Chitosan Nanomicelles of Small Size.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,37(7),1229-1231. |
| MLA | Li Hong,et al."New Tanshinone IIA Delivery System Using Chitosan Nanomicelles of Small Size".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 37.7(2016):1229-1231. |
入库方式： OAI收割
来源：化学研究所
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