A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals
文献类型：期刊论文
| 作者 | Guan, Mirong1,2; Li, Jie1,2; Jia, Qingyan3; Ge, Jiechao3; Chen, Daiqin1,2; Zhou, Yue1,2; Wang, Pengfei3; Zou, Toujun1,2; Zhen, Mingming1,2; Wang, Chunru1,2 |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2016-09-07 |
| 卷号 | 5期号:17页码:2283-2294 |
| 关键词 | clearance imaging nanocarbon photodynamic therapy theranostics |
| 英文摘要 | Nanocarbons such as carbon nanotubes, graphene derivatives, and carbon nanohorns have illustrated their potential uses as cancer theranostics owing to their intrinsic fluorescence or NIR absorbance as well as superior cargo loading capacity. However, some problems still need to be addressed, such as the fates and long-term toxicology of different nanocarbons in vivo and the improvement of their performance in various biomedical imaging-guided cancer therapy systems. Herein, a versatile and clearable nanocarbon theranostic based on carbon dots (CDs) and gadolinium metallofullerene nanocrystals (GFNCs) is first developed, in which GFNCs enhance the tumor accumulation of CDs, and CDs enhance the relaxivity of GFNCs, leading to an efficient multimodal imaging-guided photodynamic therapy in vivo without obvious long-term toxicity. Furthermore, biochemical analysis reveals that the novel nanotheranostic can harmlessly eliminate from the body in a reasonable period of time after exerting diagnostic and therapeutic function. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35312]  |
| 专题 | 化学研究所_分子纳米结构与纳米技术实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China 2.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, TIPC, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Mirong,Li, Jie,Jia, Qingyan,et al. A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals[J]. ADVANCED HEALTHCARE MATERIALS,2016,5(17):2283-2294. |
| APA | Guan, Mirong.,Li, Jie.,Jia, Qingyan.,Ge, Jiechao.,Chen, Daiqin.,...&Shu, Chunying.(2016).A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals.ADVANCED HEALTHCARE MATERIALS,5(17),2283-2294. |
| MLA | Guan, Mirong,et al."A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals".ADVANCED HEALTHCARE MATERIALS 5.17(2016):2283-2294. |
入库方式： OAI收割
来源：化学研究所
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