3-Azidoazetidines as the first scaffolds for beta-amino azetidine carboxylic acid peptidomimetics: azetidine iminosugars containing an acetamido group do not inhibit beta-N-acetylhexosaminidases
文献类型：期刊论文
| 作者 | Liu, Zilei1; Jenkinson, Sarah F.1; Kato, Atsushi2; Nakagawa, Shinpei2; Wormald, Mark R.3; Yu, Chu-Yi4,5; Fleet, George W. J.1,5 |
| 刊名 | TETRAHEDRON-ASYMMETRY
 |
| 出版日期 | 2016-10-01 |
| 卷号 | 27期号:17-18页码:872-881 |
| 英文摘要 | Stable amides and oligopeptides derived from methyl trans,trans-3-azido-4-hydroxymethyl-L-azetidine carboxylate, prepared in 19% yield from diacetone allose, is the first example of a beta-amino-azetidine carboxylic acid incorporated into peptidomimetics and provides a scaffold for investigating secondary structure induced by a novel beta-amino acid. A number of azetidine iminosugars containing a NHAc substituent were prepared but none of them were beta-N-acetylhexosaminidase inhibitors. (C) 2016 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35282]  |
| 专题 | 化学研究所_分子识别与功能实验室 |
| 作者单位 | 1.Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England 2.Toyama Univ, Dept Hosp Pharm, Toyama 9300194, Japan 3.Univ Oxford, Dept Biochem, Glycobiol Inst, Oxford OX1 3QU, England 4.Chinese Acad Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 5.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zilei,Jenkinson, Sarah F.,Kato, Atsushi,et al. 3-Azidoazetidines as the first scaffolds for beta-amino azetidine carboxylic acid peptidomimetics: azetidine iminosugars containing an acetamido group do not inhibit beta-N-acetylhexosaminidases[J]. TETRAHEDRON-ASYMMETRY,2016,27(17-18):872-881. |
| APA | Liu, Zilei.,Jenkinson, Sarah F..,Kato, Atsushi.,Nakagawa, Shinpei.,Wormald, Mark R..,...&Fleet, George W. J..(2016).3-Azidoazetidines as the first scaffolds for beta-amino azetidine carboxylic acid peptidomimetics: azetidine iminosugars containing an acetamido group do not inhibit beta-N-acetylhexosaminidases.TETRAHEDRON-ASYMMETRY,27(17-18),872-881. |
| MLA | Liu, Zilei,et al."3-Azidoazetidines as the first scaffolds for beta-amino azetidine carboxylic acid peptidomimetics: azetidine iminosugars containing an acetamido group do not inhibit beta-N-acetylhexosaminidases".TETRAHEDRON-ASYMMETRY 27.17-18(2016):872-881. |
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来源：化学研究所
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