Synthesis and multimodal responsiveness of poly(alpha-amino acid)s bearing OEGylated azobenzene side-chains
文献类型：期刊论文
| 作者 | Xiong, Wei1; Fu, Xiaohui2; Wan, Yaoming3; Sun, Yunlong1; Li, Zhibo2; Lu, Hua1 |
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2016 |
| 卷号 | 7期号:41页码:6375-6382 |
| 英文摘要 | Stimuli-responsive poly(alpha-amino acids) (P alpha AAs) are protein mimics that can alter their conformational or other physicochemical properties in response to external triggers. We report here the synthesis and characterization of novel photo and thermal responsive P alpha AAs by the ring-opening polymerization of alpha-amino acid N-carboxyanhydrides (NCAs). Specifically, a series of NCA monomers bearing azobenzene (Azo) and oligoethylene glycol (OEG) of different lengths (OEG(m)-AzoNCA, m = 2, 4, 6) are synthesized in a modular route and polymerized in a controlled manner using hexamethyldisilazane (HMDS) as the initiator. The afforded P(OEG(m)-Azo)(n)s show interesting aggregation behaviors in both organic and aqueous solutions. Moreover, P(OEG(m)-Azo)(n)s exhibit a reversible photo-responsiveness accompanied by the conformational switch of the peptidic backbone, and an irreversible thermal-responsiveness. This new biodegradable and stimuli-responsive system holds considerable promise for applications such as on-demand delivery, liquid crystalline, and hierarchical self-assembly. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35152]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Peking Univ, Beijing Natl Lab Mol Sci, Ctr Soft Matter Sci & Engn, Lab Polymer Chem & Phys,Minist Educ,Coll Chem & M, Beijing 100871, Peoples R China 2.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Qingdao 266042, Peoples R China 3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Lab Polymer Phys & Chem, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiong, Wei,Fu, Xiaohui,Wan, Yaoming,et al. Synthesis and multimodal responsiveness of poly(alpha-amino acid)s bearing OEGylated azobenzene side-chains[J]. POLYMER CHEMISTRY,2016,7(41):6375-6382. |
| APA | Xiong, Wei,Fu, Xiaohui,Wan, Yaoming,Sun, Yunlong,Li, Zhibo,&Lu, Hua.(2016).Synthesis and multimodal responsiveness of poly(alpha-amino acid)s bearing OEGylated azobenzene side-chains.POLYMER CHEMISTRY,7(41),6375-6382. |
| MLA | Xiong, Wei,et al."Synthesis and multimodal responsiveness of poly(alpha-amino acid)s bearing OEGylated azobenzene side-chains".POLYMER CHEMISTRY 7.41(2016):6375-6382. |
入库方式： OAI收割
来源：化学研究所
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