Solely Abluminal Drug Release From Coronary Stents Could Possibly Improve Reendothelialization
文献类型：期刊论文
| 作者 | Zhang, Haijun1,2; Deng, Wei3; Wang, Xiangfei2; Wang, Shenguo1,4; Ge, Junbo2; Toft, Egon1,5 |
| 刊名 | CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 88期号:3页码:E59-E66 |
| 关键词 | biodegradable polymer sirolimus drug eluting stent animal experiment coronary arteries abluminal drug elution |
| 英文摘要 | Objectives: To compare a new stent with an asymmetric coating, eluting the drug to the abluminal surface, to a stent with a conventional coating eluting the drug both to the luminal and the abluminal side. Background: Stents with asymmetric coating, eluting the drug to the vessel wall (BPSES-A), could potentially give faster reendothelialization after percutaneous coronary interventions (PCI) and decrease in in-stent thrombosis and late restenosis. Methods: BPSES-A, conventional coated stents (BPSES-C), biodegradable polymer stents without drug (BPS, for control), and bare metal stents (BMS, for control) were implanted into the coronary arteries of 38 pigs (75 stents). Pigs were sacrificed after 4, 12, and 24 weeks. Quantitative coronary angiography was used to compare in-stent late lumen loss (LLL) and electron microscopy was used to reveal levels of reendothelialization. Results: The stents were all successfully implanted. LLL of BPSES-A, BPSES-C, BMS, and BPS were 0.56 +/- 0.51, 0.60 +/- 0.58, 0.89 +/- 0.43, and 1.68 +/- 0.30 mm, respectively, after 4 weeks. LLL of BPSES-A and BPSES-C were 0.63 +/- 0.53 and 0.69 +/- 0.24 mm, respectively, after 12 weeks. LLL of BPSES-A, BPSES-C, and BMS were 0.42 +/- 0.15 m, 0.56 +/- 0.28 mm, and 0.99 +/- 0.13 mm, respectively, after 24 weeks. The scaling of reendothelialization was as follows: after 4 weeks BMS> = BPS>BPSES-A>BPSES-C, after 12 weeks BPSES-A>BPSES-C, and after 24 weeks BMS>BPSES-A>BPSES-C. Reendothelialization was better in BPSES-A than BPSES-C (P<0.05). There was no correlation between LLL and reendothelialization (P=0.42). Conclusion: Asymmetric coating of coronary stents might be helpful to improve reendothelialization. (C) 2016 Wiley Periodicals, Inc. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35169]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Aalborg Univ, Fac Med, Dept Hlth Sci & Technol, Aalborg O, Denmark 2.Fudan Univ, Shanghai Inst Cardiovasc Dis, Zhongshan Hosp, Shanghai, Peoples R China 3.Fudan Univ, Sch Publ Hlth, Key Lab Publ Hlth Safety, Minist Educ, Shanghai, Peoples R China 4.Chinese Acad Sci, Inst Chem, Beijing, Peoples R China 5.Qatar Univ, Coll Med, Biomed Res Ctr, Postbox 2716, Doha, Qatar |
| 推荐引用方式 GB/T 7714 | Zhang, Haijun,Deng, Wei,Wang, Xiangfei,et al. Solely Abluminal Drug Release From Coronary Stents Could Possibly Improve Reendothelialization[J]. CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS,2016,88(3):E59-E66. |
| APA | Zhang, Haijun,Deng, Wei,Wang, Xiangfei,Wang, Shenguo,Ge, Junbo,&Toft, Egon.(2016).Solely Abluminal Drug Release From Coronary Stents Could Possibly Improve Reendothelialization.CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS,88(3),E59-E66. |
| MLA | Zhang, Haijun,et al."Solely Abluminal Drug Release From Coronary Stents Could Possibly Improve Reendothelialization".CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS 88.3(2016):E59-E66. |
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来源：化学研究所
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