Single cell migration dynamics mediated by geometric confinement
文献类型：期刊论文
| 作者 | Zhang, Hua1; Hou, Ruixia1; Xiao, Peng1; Xing, Rubo2; Chen, Tao1; Han, Yanchun2; Ren, Penggang3; Fu, Jun1 |
| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
 |
| 出版日期 | 2016-09-01 |
| 卷号 | 145页码:72-78 |
| 关键词 | Graphene oxide micropatterns Osteoblasts Cell migration Cytoskeleton contractility |
| 英文摘要 | The migration dynamics of cells plays a key role in tissue engineering and regenerative medicine. Previous studies mostly focus on regulating stem cell fate and phenotype by biophysical cues. In contrast, less is known about how the geometric cues mediate the migration dynamics of cells. Here, we fabricate graphene oxide (GO) microstripes on cell non-adhesive PEG substrate by using micromolding in capillary (MIMIC) method. Such micropatterns with alternating cell adhesion and cell resistance enable an effective control of selective adhesion and migration of single cells. The sharp contrast in cell adhesion minimizes the invasion of cells into the PEG patterns, and thereby strongly confines the cells on GO microstripes. As a result, the cells are forced to adapt highly polarized, elongated, and oriented geometry to fit the patterns. A series of pattern widths have been fabricated to modulate the extent of cell deformation and polarization. Under strong confinement, the cytoskeleton contractility, intracellular traction, and actin filament elongation are highly promoted, which result in enhanced cell migration along the patterns. This work provides an important insight into developing combinatorial graphene-based patterns for the control of cell migration dynamics, which is of great significance for tissue engineering and regenerative medicine. (C) 2016 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35296]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, Ningbo 315201, Zhejiang, Peoples R China 2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 3.Xian Univ Technol, Inst Printing & Packaging Engn, Xian 710048, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Hua,Hou, Ruixia,Xiao, Peng,et al. Single cell migration dynamics mediated by geometric confinement[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2016,145:72-78. |
| APA | Zhang, Hua.,Hou, Ruixia.,Xiao, Peng.,Xing, Rubo.,Chen, Tao.,...&Fu, Jun.(2016).Single cell migration dynamics mediated by geometric confinement.COLLOIDS AND SURFACES B-BIOINTERFACES,145,72-78. |
| MLA | Zhang, Hua,et al."Single cell migration dynamics mediated by geometric confinement".COLLOIDS AND SURFACES B-BIOINTERFACES 145(2016):72-78. |
入库方式： OAI收割
来源：化学研究所
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