Biodegradable thermal- and redox-responsive poly(L-glutamate) with Y-shaped oligo(ethylene glycol) side-chain and tunable phase transition temperature
文献类型：期刊论文
| 作者 | Fu, Xiaohui1,2; Ma, Yinan2; Sun, Jing2; Li, Zhibo1,2 |
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2016 |
| 卷号 | 6期号:74页码:70243-70250 |
| 英文摘要 | A series of poly(L-glutamate) bearing Y-shaped oligo(ethylene glycol)(x) (OEG(x)) side-chains (PPLG-g-EG(x), x = 2, 3 and 4) were synthesized via a combination of ring opening polymerization (ROP) of gamma-propargyl-L-glutamate N-carboxyanhydride (PLG-NCA) with thiol-yne photoaddition. The solubility of the polypeptides in water was firstly investigated. PPLG-g-EG(3) and PPLG-g-EG(4) were soluble in water and displayed fully reversible thermal-responsive behaviors. Additionally, the polypeptides showed redox-responsive properties along with the conformation associated water solubility due to the presence of thioether groups in the side-chains. In particular, the clouding points (CPs) of the polypeptides are highly tunable depending on the degree of polymerization (DP), the side-chain length, the polymer/salt concentration, and the degree of oxidation/reduction. The key feature of our design is the simultaneous incorporation of thermal-responsive OEG units and redox-responsive thioether linkages by one-step thiol-yne photoaddition, which allows for precisely tuning the phase transition temperature by both stimuli. This synthetic approach offers a facile and efficient way to prepare polypeptide-based biomaterials with highly tunable properties. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35354]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Qingdao 266042, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Xiaohui,Ma, Yinan,Sun, Jing,et al. Biodegradable thermal- and redox-responsive poly(L-glutamate) with Y-shaped oligo(ethylene glycol) side-chain and tunable phase transition temperature[J]. RSC ADVANCES,2016,6(74):70243-70250. |
| APA | Fu, Xiaohui,Ma, Yinan,Sun, Jing,&Li, Zhibo.(2016).Biodegradable thermal- and redox-responsive poly(L-glutamate) with Y-shaped oligo(ethylene glycol) side-chain and tunable phase transition temperature.RSC ADVANCES,6(74),70243-70250. |
| MLA | Fu, Xiaohui,et al."Biodegradable thermal- and redox-responsive poly(L-glutamate) with Y-shaped oligo(ethylene glycol) side-chain and tunable phase transition temperature".RSC ADVANCES 6.74(2016):70243-70250. |
入库方式： OAI收割
来源：化学研究所
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