Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery
文献类型：期刊论文
| 作者 | Han, Quju1,2; Wang, Weizhi1; Jia, Xiangqian1,2; Qian, Yixia1; Li, Qian4; Wang, Zihua1; Zhang, Weikai1,5; Yang, Shu1; Jia, Yunhong3; Hu, Zhiyuan1 |
| 刊名 | ACS Applied Materials & Interfaces
 |
| 出版日期 | 2016-07-27 |
| 卷号 | 8期号:29页码:18658-18663 |
| 关键词 | switchable liposomes pH-responsive peptide VEGFR2 drug delivery cancer therapy |
| 英文摘要 | One switchable nanodelivery system was constructed. Liposomes were functionalized by a novel dual-recognition peptide STP, which is pH-responsive as well as the affinity ligand of tumor marker VEGFR2 (the angiogenesis marker vascular endothelial growth factor receptor 2). Efficient drug delivery and in-vivo therapy could be "turned on" and accelerated only in the conditions of VEGFR2 overexpression and a mild acidic environment. We envisioned that the successful demonstration of this switchable nanocarrier system would open a new avenue on rapid cytoplasmic delivery for specific cancer diagnostics and therapeutics. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35207]  |
| 专题 | 化学研究所_工程塑料实验室 |
| 作者单位 | 1.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China 2.Jinzhou Med Univ, Coll Pharm, Jinzhou 121001, Liaoning, Peoples R China 3.Jinzhou Med Univ, Coll Basic Sci, Jinzhou 121001, Liaoning, Peoples R China 4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 5.Henan Univ Sci & Technol, Coll Med, Luoyang 471003, Henan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, Quju,Wang, Weizhi,Jia, Xiangqian,et al. Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery[J]. ACS Applied Materials & Interfaces,2016,8(29):18658-18663. |
| APA | Han, Quju.,Wang, Weizhi.,Jia, Xiangqian.,Qian, Yixia.,Li, Qian.,...&Hu, Zhiyuan.(2016).Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery.ACS Applied Materials & Interfaces,8(29),18658-18663. |
| MLA | Han, Quju,et al."Switchable Liposomes: Targeting-Peptide-Functionalized and pH-Triggered Cytoplasmic Delivery".ACS Applied Materials & Interfaces 8.29(2016):18658-18663. |
入库方式： OAI收割
来源：化学研究所
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