Gold Nanoparticles Modify the Photophysical and Photochemical Properties of 6-Thioguanine: Preventing DNA Oxidative Damage
文献类型：期刊论文
| 作者 | Wang, Rennian1,3; Yue, Ling2; Yu, Youqing1; Zou, Xiaoran1; Song, Di1; Liu, Kunhui2; Liu, Yajun2; Su, Hongmei1,2,3 |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY C
 |
| 出版日期 | 2016-07-07 |
| 卷号 | 120期号:26页码:14410-14415 |
| 英文摘要 | For the widely used anticancer, antiinflammatory, and immunosuppressant drug 6-thioguanine (6-TG), its unique photochemistry of absorbing UVA, generating singlet oxygen (O-1(2)), and inducing oxidative DNA damage can cause severe phototoxicity side effects in biomedical applications. Here we raise a new strategy of loading 6-TG onto gold nanoparticles (AuNPs) and demonstrate from systematic ultraviolet irradiation experiments that the 6-TG photochemistry can be successfully modulated by binding with AuNPs and the phototoxicity under UVA irradiation are effectively removed, not only for single base 6-TG but also for 6-TG embedded in DNA. In conjunction with excited state ab initio calculations, the molecular mechanisms are further unveiled, accounting for the protection effects of AuNPs in prohibiting the 6-TG photoactivation and O-1(2) oxidation. These findings point to tremendous possibilities of using AuNPs as inert carrier to modify excited state photochemistry and prevent unwanted phototoxicity effects of the adsorbed drug molecules. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/35189]  |
| 专题 | 化学研究所_光化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, BNLMS, Inst Chem, Beijing 100190, Peoples R China 2.Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Rennian,Yue, Ling,Yu, Youqing,et al. Gold Nanoparticles Modify the Photophysical and Photochemical Properties of 6-Thioguanine: Preventing DNA Oxidative Damage[J]. JOURNAL OF PHYSICAL CHEMISTRY C,2016,120(26):14410-14415. |
| APA | Wang, Rennian.,Yue, Ling.,Yu, Youqing.,Zou, Xiaoran.,Song, Di.,...&Su, Hongmei.(2016).Gold Nanoparticles Modify the Photophysical and Photochemical Properties of 6-Thioguanine: Preventing DNA Oxidative Damage.JOURNAL OF PHYSICAL CHEMISTRY C,120(26),14410-14415. |
| MLA | Wang, Rennian,et al."Gold Nanoparticles Modify the Photophysical and Photochemical Properties of 6-Thioguanine: Preventing DNA Oxidative Damage".JOURNAL OF PHYSICAL CHEMISTRY C 120.26(2016):14410-14415. |
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来源：化学研究所
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