Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice
文献类型：期刊论文
| 作者 | Liu, Jing; Law, Wing-Cheung; Liu, Jianwei; Hu, Rui; Liu, Liwei; Zhu, Jing; Chen, Hongyan; Wang, Jianhua; Hu, Yazhuo; Ye, Ling |
| 刊名 | rsc adv.
 |
| 出版日期 | 2013 |
| 卷号 | 3期号:6页码:1768 |
| 通讯作者 | liu, j (reprint author), chinese peoples liberat army gen hosp, inst gerontol & geriatr, beijing 100853, peoples r china. |
| 英文摘要 | cadmium-based quantum dots (qds) have been extensively used for biomedical applications for the last decade. they have also been researched for drug and gene delivery. for this reason, efforts have been placed on evaluating their toxicity at in vivo level. the most widely used quantum dots are cdse qds and thus it is important for one to investigate the potential toxicity in vivo. in this contribution, we systematically study the effect of phospholipid micelle-encapsulated cdse/cds/zns qds on the long term in vivo toxicity in kunming mice. the biodistribution, animal survival, animal weight, hematology, blood biochemistry, and organ histology and their respective fluorescent images were determined at an overdose (50 mg kg(-1)) of phospholipid micelle-encapsulated qds over 112 days (16 weeks) period. the results show that the phospholipid micelle-encapsulated qds formulation did not result in noticeable toxicity. serum analysis has shown no changes in the treated mice when compared to mice treated with pbs buffer solution. histological analysis of tissues from major organs indicated that there are no acute toxic effects of the qds in vivo. fluorescent images indicated that the majority of the qds accumulated in the liver and spleen. due to the widespread use of cd-based qds and the potential for clinical use, these results are necessary and confirm the minimal health risk to use qds as optical contrast agents and therapeutic carriers. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 版本 | 出版稿 |
| 源URL | [http://ir.siom.ac.cn/handle/181231/14830]  |
| 专题 | 上海光学精密机械研究所_信息光学与光电技术实验室 |
| 作者单位 | 1.[Liu, Jing 2.Liu, Jianwei 3.Chen, Hongyan 4.Wang, Jianhua 5.Hu, Yazhuo 6.Ye, Ling] Chinese Peoples Liberat Army Gen Hosp, Inst Gerontol & Geriatr, Beijing 100853, Peoples R China 7.[Law, Wing-Cheung] SUNY Buffalo, Inst Lasers Photon & Biophoton, Buffalo, NY 14260 USA 8.[Hu, Rui 9.Yong, Ken-Tye] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore 10.[Liu, Liwei] Changchun Univ Sci & Technol, Sch Sci, Changchun 130022, Jilin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jing,Law, Wing-Cheung,Liu, Jianwei,et al. Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice[J]. rsc adv.,2013,3(6):1768. |
| APA | Liu, Jing.,Law, Wing-Cheung.,Liu, Jianwei.,Hu, Rui.,Liu, Liwei.,...&Yong, Ken-Tye.(2013).Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice.rsc adv.,3(6),1768. |
| MLA | Liu, Jing,et al."Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice".rsc adv. 3.6(2013):1768. |
入库方式： OAI收割
来源：上海光学精密机械研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。