Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human
文献类型：期刊论文
| 作者 | Yang FT1,2; Graphodatsky AS3; O'Brien PCM1; Colabella A1; Solanky N1; Squire M1; Sargan DR1; Ferguson-Smith MA[*]1 |
| 刊名 | CHROMOSOME RESEARCH
 |
| 出版日期 | 2000 |
| 卷号 | 8期号:5页码:393-404 |
| 关键词 | cat chromosome painting comparative mapping dog evolution human |
| ISSN号 | 0967-3849 |
| 通讯作者 | maf12@mole.bio.cam.ac.uk |
| 合作状况 | 其它 |
| 英文摘要 | Domestic cats and dogs are important companion animals and model animals in biomedical research. The cat has a highly conserved karyotype, closely resembling the ancestral karyotype of mammals, while the dog has one of the most extensively rearranged mammalian karyotypes investigated so far. We have constructed the first detailed comparative chromosome map of the domestic dog and cat by reciprocal chromosome painting. Dog paints specific for the 38 autosomes and the X chromosomes delineated 68 conserved chromosomal segments in the cat, while reverse painting of cat probes onto red fox and dog chromosomes revealed 65 conserved segments. Most conserved segments on cat chromosomes also show a high degree of conservation in G-banding patterns compared with their canine counterparts. At least 47 chromosomal fissions (breaks), 25 fusions and one inversion are needed to convert the cat karyotype to that of the dog, confirming that extensive chromosome rearrangements differentiate the karyotypes of the cat and dog. Comparative analysis of the distribution patterns of conserved segments defined by dog paints on cat and human chromosomes has refined the human/cat comparative genome map and, most importantly, has revealed 15 cryptic inversions in seven large chromosomal regions of conserved synteny between humans and cats. |
| 收录类别 | SCI |
| 资助信息 | A. S. Graphodatsky is supported by research grants for the Russian Fund for Basic Research. |
| 原文出处 | 20008393.pdf |
| 语种 | 中文 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/1997]  |
| 专题 | 昆明动物研究所_其他 |
| 作者单位 | 1.Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 0ES, UK 2.Kunming Institute of Zoology, The Chinese Academy of Sciences, Kunming, Yunnan 650223, P. R. China 3.Institute of Cytology and Genetics, SB RAS 6300090, Novosibirsk, Russia |
| 推荐引用方式 GB/T 7714 | Yang FT,Graphodatsky AS,O'Brien PCM,et al. Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human[J]. CHROMOSOME RESEARCH,2000,8(5):393-404. |
| APA | Yang FT.,Graphodatsky AS.,O'Brien PCM.,Colabella A.,Solanky N.,...&Ferguson-Smith MA[*].(2000).Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human.CHROMOSOME RESEARCH,8(5),393-404. |
| MLA | Yang FT,et al."Reciprocal chromosome painting illuminates the history of genome evolution of the domestic cat, dog and human".CHROMOSOME RESEARCH 8.5(2000):393-404. |
入库方式： OAI收割
来源：昆明动物研究所
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