Karyotype evolution of giraffes ( Giraffa camelopardalis ) revealed by cross-species chromosome painting with Chinese muntjac ( Muntiacus reevesi ) and human ( Homo sapiens ) paints
文献类型：期刊论文
| 作者 | Huang L[*]1,2; Nesterenko A3; Nie W2; Wang J2; Su W2; Graphodatsky AS3; Yang F4 |
| 刊名 | CYTOGENETIC AND GENOME RESEARCH
 |
| 出版日期 | 2008 |
| 卷号 | 122期号:2页码:132–138 |
| 通讯作者 | huangdl@126.com |
| 合作状况 | 其它 |
| 英文摘要 | Considering the giraffe (Giraffa camelopardalis, GCA, 2n = 30) as a primitive species, its comparative genomic data are critical for our understanding of the karyotype evolution of pecorans. Here, we have established genome-wide chromosomal homologies between giraffe, Chinese muntjac (Muntiacus reevesi, MRE, 2n = 46) and human (Homo sapiens, HSA, 2n = 46) with whole sets of chromosome-specific paints from Chinese muntjac and human, in addition to providing a high-resolution G-banding karyotype of giraffe. Chinese muntjac and human chromosome paints detected 32 and 45 autosomal homologs in the genome of giraffe, respectively. Our results suggest that it would require at least thirteen fissions, six fusions and three intrachromosomal rearrangements to 'transform' the 2n = 44 eutherian ancestral karyotype to the 2n = 58 pecoran ancestral karyotype. During giraffe evolution, some ancestral eutherian syntenies (i.e. association of HSA3/21, 4/8, 7/16, 14/15, 16/19 and two forms of 12/22) have been retained, while several derived syntenies (i.e. associations of human homologous segments 2/1, 2/9, 5/19, 4/12/22, 8/9, and 10/20) have been produced. The reduction of chromosome number in giraffe from the 2n = 58 pecoran ancestral karyotype could be primarily attributed to extensive Robertsonian translocations of ancestral chromosomal segments. More complex chromosomal rearrangements (including tandem fusion, centromere repositioning and pericentric inversion) have happened during the evolution of GCA2 and GCA8. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the National Natural Science Foundation of China (No. 30700473), start-up fund from the Ludong University and in part by the MCB, RFBR, BOE Research Grants (to A.S.G.). |
| 语种 | 英语 |
| 公开日期 | 2010-11-10 |
| 源URL | [http://159.226.149.42:8088/handle/152453/6381]  |
| 专题 | 昆明动物研究所_保护遗传学(细胞库) 昆明动物研究所_遗传资源与进化国家重点实验室 |
| 作者单位 | 1.College of Life Sciences, Ludong University, Yantai 2.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan (P.R. China) 3.Institute of Cytology and Genetics, Novosibirsk (Russia) 4.Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge (UK) |
| 推荐引用方式 GB/T 7714 | Huang L[*],Nesterenko A,Nie W,et al. Karyotype evolution of giraffes ( Giraffa camelopardalis ) revealed by cross-species chromosome painting with Chinese muntjac ( Muntiacus reevesi ) and human ( Homo sapiens ) paints[J]. CYTOGENETIC AND GENOME RESEARCH,2008,122(2):132–138. |
| APA | Huang L[*].,Nesterenko A.,Nie W.,Wang J.,Su W.,...&Yang F.(2008).Karyotype evolution of giraffes ( Giraffa camelopardalis ) revealed by cross-species chromosome painting with Chinese muntjac ( Muntiacus reevesi ) and human ( Homo sapiens ) paints.CYTOGENETIC AND GENOME RESEARCH,122(2),132–138. |
| MLA | Huang L[*],et al."Karyotype evolution of giraffes ( Giraffa camelopardalis ) revealed by cross-species chromosome painting with Chinese muntjac ( Muntiacus reevesi ) and human ( Homo sapiens ) paints".CYTOGENETIC AND GENOME RESEARCH 122.2(2008):132–138. |
入库方式： OAI收割
来源：昆明动物研究所
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