Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability
文献类型：期刊论文
| 作者 | Zhao B1,2; Zhang WD1,2,3; Duan YL1,2; Lu YQ1,2; Cun YX1,2; Li CH1,2,3; Guo K1,2,3; Nie WH1; Li L4; Zhang RG5 |
| 刊名 | CELL STEM CELL
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:6页码:684-698 |
| 通讯作者 | zhengp@mail.kiz.ac.cn |
| 合作状况 | 其它 |
| 英文摘要 | Pluripotent stem cells (PSCs) hold great promise in cell-based therapy, but the genomic instability seen in culture hampers their full application. A greater understanding of the factors that regulate genomic stability in PSCs could help address this issue. Here we describe the identification of Filia as a specific regulator of genomic stability in mouse embryonic stem cells (ESCs). Filia expression is induced by genotoxic stress. Filia promotes centrosome integrity and regulates the DNA damage response (DDR) through multiple pathways, including DDR signaling, cell-cycle checkpoints and damage repair, ESC differentiation, and apoptosis. Filia depletion causes ESC genomic instability, induces resistance to apoptosis, and promotes malignant transformation. As part of its role in DDR, Filia interacts with PARP1 and stimulates its enzymatic activity. Filia also constitutively resides on centrosomes and translocates to DNA damage sites and mitochondria, consistent with its multifaceted roles in regulating centrosome integrity, damage repair, and apoptosis. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Chinese NSFC grant 31171424 (to P.Z.), by CAS Strategic Priority Research Program Grant XDA01010203, and by a talent grant from Yunnan Province. R.Z. is supported by NIH/NCI Grant R01CA160331 and Cancer Center Core Grant CA010815. |
| 语种 | 英语 |
| 公开日期 | 2015-05-08 |
| 源URL | [http://159.226.149.42:8088/handle/152453/8325]  |
| 专题 | 昆明动物研究所_哺乳动物胚胎发育 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_保护遗传学(细胞库) |
| 作者单位 | 1.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 2.Yunnan Key Laboratory of Animal Reproduction, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China 3.Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China 4.State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China 5.Gene Expression and Regulation Program, The Wistar Institute Cancer Center, The Wistar Institute, Philadelphia, PA 19104, USA |
| 推荐引用方式 GB/T 7714 | Zhao B,Zhang WD,Duan YL,et al. Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability[J]. CELL STEM CELL,2015,16(6):684-698. |
| APA | Zhao B.,Zhang WD.,Duan YL.,Lu YQ.,Cun YX.,...&Zheng P[*].(2015).Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.CELL STEM CELL,16(6),684-698. |
| MLA | Zhao B,et al."Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability".CELL STEM CELL 16.6(2015):684-698. |
入库方式： OAI收割
来源：昆明动物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。