Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging
文献类型：期刊论文
| 作者 | Sun SJ1; Jiang P2; Su WT3; Xiang Y[*]4; Li J5; Zeng L5; Yang SJ5 |
| 刊名 | CYTOTECHNOLOGY
 |
| 出版日期 | 2016 |
| 卷号 | 68期号:2页码:229-240 |
| 关键词 | Wild chrysanthemum Chrysanthemum indicum L Ultraviolet Cell death Photoaging Anti-oxidant |
| 通讯作者 | yang_xiang000@hotmail.com |
| 合作状况 | 其它 |
| 英文摘要 | Wild chrysanthemum (Chrysanthemum indicum L.) is traditionally used in folk medicine as an anti-inflammatory agent. It is also used in the southwest plateau region of China to prevent ultraviolet-induced skin damage. However, the role and mechanism by which wild chrysanthemum prevents UV-induced skin damage and photoaging have never been investigated in vitro. In the present study, we found that aqueous extracts from wild chrysanthemum strongly reduced high-dose UVB-induced acute cell death of human immortalized keratinocytic HaCat cells. Wild chrysanthemum extract was also demonstrated to reduce low-dose UVB-induced expression of the photoaging-related matrix metalloproteinases MMP-2 and MMP-9. The ROS level elevated by UVB irradiation was strongly attenuated by wild chrysanthemum extract. Further study revealed that wild chrysanthemum extract reduced UVB-triggered ERK1/2 and p38 MAPK phosphorylation and their protective role, which is partially dependent on inhibiting p38 activation. These results suggest that wild chrysanthemum extract can protect the skin from UVB-induced acute skin damage and photoaging by reducing the intracellular reactive oxygen species (ROS) level and inhibiting p38 MAPK phosphorylation. The present study confirmed the protective role of wild chrysanthemum against UV-induced skin disorders in vitro and indicated the possible mechanism. Further study to identify the active components in wild chrysanthemum extract would be useful for developing new drugs for preventing and treating skin diseases, including skin cancer and photoaging, induced by UV irradiation. |
| 收录类别 | SCI |
| 资助信息 | This work was supported by the Scientific Research Fund Project of the Yunnan Province Department of Education (2012Y149), Chinese National Natural Science Foundation (31301884, 81160302) and technological innovation projects of Chinese Academy of Sciences (022006). |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/9578]  |
| 专题 | 昆明动物研究所_保护遗传学(细胞库) 昆明动物研究所_动物模型与人类重大疾病机理重点实验室 昆明动物研究所_遗传资源与进化国家重点实验室 昆明动物研究所_动物活性蛋白多肽组学 管理、支撑部门_大型仪器中心 |
| 作者单位 | 1.Department of Cosmetology, The Affiliated Hospital of Dali College, Dali 671000, Yunnan, China 2.Department of Pathology, Kunming Medical University, Kunming 650032, Yunnan, China 3.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China 4.Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, The Chinese Academy of Sciences, 32 East Jiao Chang Road, Kunming 650223, Yunnan, China 5.Kunming Biological Diversity Regional Center of Large Apparatuses and Equipment, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China |
| 推荐引用方式 GB/T 7714 | Sun SJ,Jiang P,Su WT,et al. Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging[J]. CYTOTECHNOLOGY,2016,68(2):229-240. |
| APA | Sun SJ.,Jiang P.,Su WT.,Xiang Y[*].,Li J.,...&Yang SJ.(2016).Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging.CYTOTECHNOLOGY,68(2),229-240. |
| MLA | Sun SJ,et al."Wild chrysanthemum extract prevents UVB radiation-induced acute cell death and photoaging".CYTOTECHNOLOGY 68.2(2016):229-240. |
入库方式： OAI收割
来源：昆明动物研究所
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