Chromosome painting between human and lorisiform prosimians: Evidence for the HSA 7/16 Synteny in the primate ancestral karyotype
文献类型：期刊论文
| 作者 | Nie WH1,2; O'Brien PCM3; Ferguson-Smith MA3; Robinson TJ4; Yang FT[*]1,3; Fu BY3; Wang JH1; Su WT1 |
| 刊名 | AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY
 |
| 出版日期 | 2006 |
| 卷号 | 129期号:2页码:250-259 |
| 关键词 | in situ hybridization chromosome evolution phylogeny slow loris |
| 通讯作者 | fy1@sanger.ac.uk |
| 合作状况 | 其它 |
| 英文摘要 | Multidirectional chromosome painting with probes derived from flow-sorted chromosomes of humans (Homo sapiens, HSA, 2n = 46) and galagos (Galago moholi, GMO, 2n = 38) allowed us to map evolutionarily conserved chromosomal segments among humans, galagos, and slow lorises (Nycticebus coucang, NCO, 2n = 50). In total, the 22 human autosomal painting probes detected 40 homologous chromosomal segments in the slow loris genome. The genome of the slow loris contains 16 sytenic associations of human homologues. The ancient syntenic associations of human chromosomes such as HSA 3/21, 7/16, 12/22 (twice), and 14/15, reported in most mammalian species, were also present in the slow loris genome. Six associations (HSA 1a/19a, 2a/12a, 6a/14b, 7a/12c, 9/15b, and 10a/19b) were shared by the slow loris and galago. Five associations (HSA 1b/6b, 4a/5a, 11b/15a, 12b/19b, and 15b/16b) were unique to the slow loris. In contrast, 30 homologous chromosome segments were identified in the slow loris genome when using galago chromosome painting probes. The data showed that the karyotypic differences between these two species were mainly due to Robertsonian translocations. Reverse painting, using galago painting probes onto human chromosomes, confirmed most of the chromosome homologies between humans and galagos established previously, and documented the HSA 7/16 association in galagos, which was not reported previously. The presence of the HSA 7/16 association in the slow loris and galago suggests that the 7/16 association is an ancestral synteny for primates. Based on our results and the published homology maps between humans and other primate species, we propose an ancestral karyotype (2n = 60) for lorisiform primates. |
| 收录类别 | SCI |
| 资助信息 | Grant sponsor: National Natural Sciences Foundation of China; Grant number: 30270719; Grant sponsor: Welcome Trust. |
| 语种 | 英语 |
| 源URL | [http://159.226.149.26:8080/handle/152453/10584]  |
| 专题 | 昆明动物研究所_保护遗传学(细胞库) 昆明动物研究所_细胞与分子进化重点实验室 |
| 作者单位 | 1.Key Laboratory of Cellular and Molecular Evolution, Chinese Academy of Sciences, Kunming, Yunnan 650223, People’s Republic of China 2.Graduate School, Chinese Academy of Sciences, Beijing 100039, People’s Republic of China 3.Centre for Veterinary Science, University of Cambridge, Cambridge CB3 0ES, UK 4.Evolutionary Genomics Group, Department of Zoology, University of Stellenbosch, Matieland 7602, South Africa |
| 推荐引用方式 GB/T 7714 | Nie WH,O'Brien PCM,Ferguson-Smith MA,et al. Chromosome painting between human and lorisiform prosimians: Evidence for the HSA 7/16 Synteny in the primate ancestral karyotype[J]. AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY,2006,129(2):250-259. |
| APA | Nie WH.,O'Brien PCM.,Ferguson-Smith MA.,Robinson TJ.,Yang FT[*].,...&Su WT.(2006).Chromosome painting between human and lorisiform prosimians: Evidence for the HSA 7/16 Synteny in the primate ancestral karyotype.AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY,129(2),250-259. |
| MLA | Nie WH,et al."Chromosome painting between human and lorisiform prosimians: Evidence for the HSA 7/16 Synteny in the primate ancestral karyotype".AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY 129.2(2006):250-259. |
入库方式： OAI收割
来源：昆明动物研究所
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