DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata
文献类型：期刊论文
| 作者 | Li, Yaoguo; Huang, Xiande; Guan, Yunyan; Shi, Yu; Zhang, Hua; He, Maoxian |
| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 45期号:2页码:912-918 |
| 关键词 | Pinctada fucata Mantle injury Galectin Promoter region DNA methylation |
| 通讯作者 | hmx@scsio.ac.cn |
| 中文摘要 | Galectin is one important member of pattern recognition proteins that plays a pivotal role in regulating innate immune response of invertebrates. In this study, we cloned the promoter sequence of a tandem-repeat galectin from the pearl oyster Pinctada fucata (P. fucata). The quantitative real-time PCR analysis revealed that galectin mRNA expression in mantle tissues were firstly up-regulated from time points of 2 h-24 h, and then down-regulated from time points of 24 h-168 h after mantle injury. The genome methylation level of mantle tissue was inversely related to galectin mRNA expression (Pearson correlation: -0.554, P: 0.154). The "CpG4-6" methylation level in promoter region of galectin was significant positive correlated with the mRNA expression (Pearson correlation: 0313, P: 0.049). The results indicated that galectin gene may be involved in immune response in mantle wound healing process of P. fucata, and DNA methylation may be a regulation factor of gene expression. (C) 2015 Elsevier Ltd. All rights reserved. |
| 学科主题 | Fisheries; Immunology; Marine & Freshwater Biology; Veterinary Sciences |
| 收录类别 | SCI |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/15056]  |
| 专题 | 南海海洋研究所_热带海洋环境国家重点实验室(LTO) |
| 推荐引用方式 GB/T 7714 | Li, Yaoguo,Huang, Xiande,Guan, Yunyan,et al. DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata[J]. FISH & SHELLFISH IMMUNOLOGY,2015,45(2):912-918. |
| APA | Li, Yaoguo,Huang, Xiande,Guan, Yunyan,Shi, Yu,Zhang, Hua,&He, Maoxian.(2015).DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata.FISH & SHELLFISH IMMUNOLOGY,45(2),912-918. |
| MLA | Li, Yaoguo,et al."DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata".FISH & SHELLFISH IMMUNOLOGY 45.2(2015):912-918. |
入库方式： OAI收割
来源：南海海洋研究所
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