Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages
文献类型：期刊论文
| 作者 | Tang, Hao; Ge, Hui; Chen, Zhi-Bin; Luo, Xiong-Ming; Su, Feng-Juan; Liang, Yan-Bing; Li, Zhen-Yu; Wu, Jing-Guo; Yang, Qing; Zeng, Li-Jin |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2015 |
| 卷号 | 13期号:9页码:5593-5605 |
| 关键词 | micrometam C inflammatory zebrafish NF-B NADPH oxidase |
| 通讯作者 | kyrintang@163.com ; gehui2009gh@126.com ; psyczb@aliyun.com ; luoxm163@sina.com ; jisufengjuan@163.com ; xuyw8591@126.com ; leezhenyu99@163.com ; wjg114500@163.com ; yangqin804@163.com ; 164555182@qq.com ; mazhongfu05@sohu.com |
| 中文摘要 | Micrometam C is a core of novel marine compound isolated from the mangrove associates Micromelum falcatum. In this study, we investigated the protective effects of micrometam C in inflammation models in the transgenic zebrafish line Tg (corola: eGFP) and RAW264.7 macrophages. We found that micrometam C significantly suppressed the migration of immune cells in tail-cutting-induced inflammation in transgenic zebrafish and reduced lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) in both zebrafish and macrophages. In addition, micrometam C also restored LPS-induced reduction of endogenous antioxidants, such as catalase (CAT), glutathione (GSH) and superoxide dismutase (SOD). The protective effects of micrometam C were in parallel to its inhibition of NADPH oxidase and nuclear factor-kappa-binding (NF-B) activity. Thus, the present results demonstrate that micrometam C protects against LPS-induced inflammation possibly through its antioxidant property. |
| 学科主题 | Pharmacology & Pharmacy |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14919]  |
| 专题 | 南海海洋研究所_热带海洋环境国家重点实验室(LTO) |
| 推荐引用方式 GB/T 7714 | Tang, Hao,Ge, Hui,Chen, Zhi-Bin,et al. Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages[J]. MARINE DRUGS,2015,13(9):5593-5605. |
| APA | Tang, Hao.,Ge, Hui.,Chen, Zhi-Bin.,Luo, Xiong-Ming.,Su, Feng-Juan.,...&Ma, Zhong-Fu.(2015).Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages.MARINE DRUGS,13(9),5593-5605. |
| MLA | Tang, Hao,et al."Micrometam C Protects against Oxidative Stress in Inflammation Models in Zebrafish and RAW264.7 Macrophages".MARINE DRUGS 13.9(2015):5593-5605. |
入库方式： OAI收割
来源：南海海洋研究所
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