Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.
文献类型：期刊论文
| 作者 | Wang, Jun-Feng1; He, Wei-Jun1; Zhang, Xiao-Xiao1; Zhao, Bi-Qing1; Liu, Yong-Hong1; Zhou, Xiao-Jiang1 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2015 |
| 卷号 | 25期号:19页码:4082-4084 |
| 关键词 | Dimeric sesquiterpene Carpesium abrotanoides L. Cytotoxic activity Antiviral activity Antimycobacterial activity |
| 通讯作者 | gale9888@163.com |
| 英文摘要 | A new dimeric sesquiterpene, dicarabrol (1), together with three known sesquiterpenes, carabrol (2), 11 (13)-dehydroivaxillin (3), and 2-desoxy-4-epi-pulchellin (4), were isolated from the whole plant of Carpesium abrotanoides L. Their structures were elucidated on the basis of spectroscopic analysis, and single crystal X-ray diffraction analysis. Compound 1 possessed a dimeric sesquiterpene core featured with a cyclopentane ring connecting two sesquiterpene lactone units rarely discovered in nature. Dicarabrol (1), as well as three known sesquiterpenes (2-4), had potent in vitro cytotoxicities against the K562, MCF-7, Hela, DU145, U937, H1975, SGC-7901, A549, MOLT-4, and HL60 cell lines with IC50 values ranging from 0.10 to 46.7 mu M, while they showed significant antiviral (H1N1 and H3N2) activities. Furthermore, compounds 1, 3 and 4 displayed significant antimycobacterial activity (IC50 3.7, 6.0, and 7.6 mu M, respectively). (C) 2015 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Chemistry |
| 原文出处 | 0960-894X |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14766]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Wang, Jun-Feng 2.He, Wei-Jun 3.Zhang, Xiao-Xiao 4.Zhao, Bi-Qing 5.Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 6.[Wang, Jun-Feng 7.Liu, Yong-Hong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, Guangdong Key Lab Marine Mat Med,CAS Key Lab Trop, Guangzhou 510301, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jun-Feng,He, Wei-Jun,Zhang, Xiao-Xiao,et al. Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(19):4082-4084. |
| APA | Wang, Jun-Feng,He, Wei-Jun,Zhang, Xiao-Xiao,Zhao, Bi-Qing,Liu, Yong-Hong,&Zhou, Xiao-Jiang.(2015).Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L..BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(19),4082-4084. |
| MLA | Wang, Jun-Feng,et al."Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.19(2015):4082-4084. |
入库方式： OAI收割
来源：南海海洋研究所
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