Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds
文献类型：期刊论文
| 作者 | Zhu, Yiguang1; Zhang, Wenjun1; Chen, Yaolong1; Yuan, Chengshan1; Zhang, Haibo1; Zhang, Guangtao1; Ma, Liang1; Zhang, Qingbo1; Tian, Xinpeng1; Zhang, Si1 |
| 刊名 | CHEMBIOCHEM
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:14页码:2086-2093 |
| 关键词 | biosynthesis heronamides hydroxylation migrated double bonds polyketides |
| 通讯作者 | czhang2006@gmail.com |
| 英文摘要 | Heronamides belong to a growing family of beta-amino acid polyketide macrolactams (beta PMs) with an unsaturated side chain. The biosynthetic gene cluster for heronamide F was identified from the deep-sea-derived Streptomyces sp. SCSIO 03032. The involvement of the gene cluster in heronamide biosynthesis was confirmed by the functional characterization of the P450 enzyme HerO as an 8-hydroxylase for tailoring heronamide biosynthesis. The presence of migrated double bonds in the conjugated diene-containing side chain of heronamides was confirmed by feeding experiments with labeled small carboxylic acid molecules. This study is the first demonstration of migrated double bonds in beta PMs with an unsaturated side chain. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 原文出处 | 1439-4227 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14769]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Zhu, Yiguang 2.Zhang, Wenjun 3.Chen, Yaolong 4.Yuan, Chengshan 5.Zhang, Haibo 6.Zhang, Guangtao 7.Ma, Liang 8.Zhang, Qingbo 9.Tian, Xinpeng 10.Zhang, Si |
| 推荐引用方式 GB/T 7714 | Zhu, Yiguang,Zhang, Wenjun,Chen, Yaolong,et al. Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds[J]. CHEMBIOCHEM,2015,16(14):2086-2093. |
| APA | Zhu, Yiguang.,Zhang, Wenjun.,Chen, Yaolong.,Yuan, Chengshan.,Zhang, Haibo.,...&Zhang, Changsheng.(2015).Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds.CHEMBIOCHEM,16(14),2086-2093. |
| MLA | Zhu, Yiguang,et al."Characterization of Heronamide Biosynthesis Reveals a Tailoring Hydroxylase and Indicates Migrated Double Bonds".CHEMBIOCHEM 16.14(2015):2086-2093. |
入库方式： OAI收割
来源：南海海洋研究所
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