Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation
文献类型：期刊论文
| 作者 | Wang, Jun-Feng1; Qin, Xiaochu1; Xu, Fu-Quan1; Zhang, Tianyu1; Liao, Shengrong1; Lin, Xiuping1; Yang, Bin1; Liu, Juan1; Wang, Lishu1; Tu, Zhengchao1 |
| 刊名 | NATURAL PRODUCT RESEARCH
 |
| 出版日期 | 2015 |
| 卷号 | 29期号:18页码:1761-1765 |
| 关键词 | marine fungus Phakellia fusca Thiele tetramic acid polyphenol anti-inflammatory activity antituberculosis activity |
| 通讯作者 | tu_zhengchao@gibh.ac.cn ; yonghongliu@scsio.ac.cn |
| 英文摘要 | Fifteen compounds, including two tetramic acid derivatives, penicillenol A(1) (1) and penicillenol A(2) (2), six polyphenols containing both phenolic bisabolane sesquiterpenoid and diphenyl ether units, expansols A-F (3-8), together with six phenolic bisabolane sesquiterpenoids (9-14) and diorcinol (15), were isolated from the fermentation broth of the marine-derived fungus ZSDS1-F11 isolated from the sponge Phakellia fusca Thiele collected in the Yongxing island of Xisha. Their structures were elucidated mainly by using extensive NMR spectroscopic and mass spectrometric analyses. Compounds 3-5, 7 and 8 showed potent COX-1 inhibitory activity with IC50 values of 5.3, 16.2, 30.2, 41.0 and 56.8M, respectively. Meanwhile, compounds 3-8 showed potent COX-2 inhibitory activity with IC50 values of 3.1, 5.6, 3.0, 5.1, 3.2 and 3.7M, respectively. In addition, compound 1 exhibited antituberculosis activity with 96.1% inhibition at concentration of 10M. |
| 学科主题 | Chemistry; Pharmacology & Pharmacy |
| 原文出处 | 1478-6419 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14771]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Wang, Jun-Feng 2.Liao, Shengrong 3.Lin, Xiuping 4.Yang, Bin 5.Liu, Juan 6.Liu, Yonghong] Chinese Acad Sci, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,South China Sea, Guangzhou 510301, Guangdong, Peoples R China 7.[Qin, Xiaochu 8.Zhang, Tianyu 9.Tu, Zhengchao] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 10.[Xu, Fu-Quan] Huaihai Inst Technol, Jiangsu Key Lab Marine Biotechnol, Lianyungang 222005, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jun-Feng,Qin, Xiaochu,Xu, Fu-Quan,et al. Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation[J]. NATURAL PRODUCT RESEARCH,2015,29(18):1761-1765. |
| APA | Wang, Jun-Feng.,Qin, Xiaochu.,Xu, Fu-Quan.,Zhang, Tianyu.,Liao, Shengrong.,...&Liu, Yonghong.(2015).Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation.NATURAL PRODUCT RESEARCH,29(18),1761-1765. |
| MLA | Wang, Jun-Feng,et al."Tetramic acid derivatives and polyphenols from sponge-derived fungus and their biological evaluation".NATURAL PRODUCT RESEARCH 29.18(2015):1761-1765. |
入库方式： OAI收割
来源：南海海洋研究所
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