The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio)
文献类型：期刊论文
| 作者 | Liang, Yan-Qiu1; Huang, Guo-Yong1; Ying, Guang-Guo1; Liu, Shuang-Shuang1; Jiang, Yu-Xia1; Liu, Shan1; Peng, Feng-Jiao1 |
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2015 |
| 卷号 | 128页码:199-206 |
| 关键词 | Hypothalamic-pituitary-gonadal axis Hypothalamic-pituitary-adrenal axis Progesterone Zebrafish |
| 通讯作者 | guangguo.ying@gmail.com |
| 英文摘要 | Progesterone (P4) has been reported in surface water, and it may have adverse effects on aquatic organisms. This study provided the transcriptional effects of P4 during the early development of zebrafish. Zebrafish embryos were exposed for 144 h post fertilization (hpf) to 0, 6, 45 and 90 ng L-1 P4, and transcriptional expression profiles of the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes were assessed every day. For the receptor signaling pathways, P4 significantly induced the transcript of Pgr gene above 45 ng L-1 at 72 and 144 hpf, but inhibited its transcript above 6 ng L-1 at 96 and 120 hpf. A significant up-regulation of Vtgl mRNA was observed at 6 ng L-1 P4 or higher at 24, 96 and 144 hpf. For the steroidogenic pathways, the transcriptional expression of Cyp11a1 and Hsd17b3 mRNAs was mediated by 6 ng L-1 P4 or higher according to different exposure time points. In addition, P4 resulted in a significant induction of Cyp19a1a and Cyp11b mRNA expression while it caused a significant inhibition of Hs11b2 mRNA expression above 6 ng L-1. For the other target genes related to hypothalamic and pituitary hormones, P4 mainly modulated the transcripts of Gnrh2, Fshb and Lhb genes at 6 ng L-1 or higher. The overall results from the present study indicate that P4 at environmentally relevant concentrations could cause the potential effects on zebrafish reproductive and adrenal endocrine systems by interfering with the HPG and HPA axes. (C) 2015 Elsevier Ltd. All rights reserved. |
| 学科主题 | Environmental Sciences & Ecology |
| 原文出处 | 0045-6535 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14830]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Liang, Yan-Qiu 2.Huang, Guo-Yong 3.Ying, Guang-Guo 4.Liu, Shuang-Shuang 5.Jiang, Yu-Xia 6.Liu, Shan 7.Peng, Feng-Jiao] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Peoples R China 8.[Liu, Shan] Chinese Acad Sci, Key Lab Marine Bioresources Sustainable Utilizat, South China Sea Inst Oceanol, Guangzhou 510301, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Yan-Qiu,Huang, Guo-Yong,Ying, Guang-Guo,et al. The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio)[J]. CHEMOSPHERE,2015,128:199-206. |
| APA | Liang, Yan-Qiu.,Huang, Guo-Yong.,Ying, Guang-Guo.,Liu, Shuang-Shuang.,Jiang, Yu-Xia.,...&Peng, Feng-Jiao.(2015).The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio).CHEMOSPHERE,128,199-206. |
| MLA | Liang, Yan-Qiu,et al."The effects of progesterone on transcriptional expression profiles of genes associated with hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes during the early development of zebrafish (Danio rerio)".CHEMOSPHERE 128(2015):199-206. |
入库方式： OAI收割
来源：南海海洋研究所
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