Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium
文献类型：期刊论文
| 作者 | Wang, Jun-Feng1; Yang, Sheng-Hui1; Liu, Yan-Qun1; Li, Din-Xiang1; He, Wei-Jun1; Zhang, Xiao-Xiao1; Liu, Yong-Hong1; Zhou, Xiao-Jiang1 |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2015 |
| 卷号 | 25期号:9页码:1986-1989 |
| 关键词 | Croton tiglium Phorbol esters Cytotoxicity Anti-inflammatory activity |
| 通讯作者 | yonghongliu@scsio.ac.cn ; gale9888@163.com |
| 英文摘要 | Five new phorbol esters, (four phorbol diesters, 1-4, and one 4-deoxy-4 alpha-phorbol diester, 5), as well as four known phorbol esters analogues (6-9) were isolated and identified from the branches and leaves of Croton tiglium. Their structures were elucidated mainly by extensive NMR spectroscopic, and mass spectrometric analysis. Among them, compound (1) was the first example of a naturally occurring phorbol ester with the 20-aldehyde group. Compounds 2-5, and 7-9 showed potent cytotoxicity against the K562, A549, DU145, H1975, MCF-7, U937, SGC-7901, HL60, Hela, and MOLT-4 cell lines, with IC50 values ranging from 1.0 to 43 mu M, while none of the compounds exhibited cytotoxic effects on normal human cell lines 293T and LX-2, respectively. In addition, compound 3 exhibited moderate COX-1 and COX-2 inhibition, with IC50 values of 0.14 and 8.5 mu M, respectively. (C) 2015 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Chemistry |
| 原文出处 | 0960-894X |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14837]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Wang, Jun-Feng 2.Yang, Sheng-Hui 3.Liu, Yan-Qun 4.He, Wei-Jun 5.Zhang, Xiao-Xiao 6.Zhou, Xiao-Jiang] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China 7.[Wang, Jun-Feng 8.Liu, Yong-Hong] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol,Guangdong Key Lab Marin, CAS Key Lab Trop Marine Bioresources & Ecol, Guangzhou 510301, Guangdong, Peoples R China 9.[Li, Din-Xiang] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & We, Changsha 410208, Hunan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jun-Feng,Yang, Sheng-Hui,Liu, Yan-Qun,et al. Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2015,25(9):1986-1989. |
| APA | Wang, Jun-Feng.,Yang, Sheng-Hui.,Liu, Yan-Qun.,Li, Din-Xiang.,He, Wei-Jun.,...&Zhou, Xiao-Jiang.(2015).Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,25(9),1986-1989. |
| MLA | Wang, Jun-Feng,et al."Five new phorbol esters with cytotoxic and selective anti-inflammatory activites from Croton tiglium".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 25.9(2015):1986-1989. |
入库方式： OAI收割
来源：南海海洋研究所
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