Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host
文献类型：期刊论文
| 作者 | Li, Qinglian1; Song, Yongxiang1; Qin, Xiangjing1; Zhang, Xing1; Sun, Aijun1; Ju, Jianhua1 |
| 刊名 | JOURNAL OF NATURAL PRODUCTS
 |
| 出版日期 | 2015 |
| 卷号 | 78期号:4页码:944-948 |
| 通讯作者 | jju@scsio.ac.cn |
| 英文摘要 | The desotamides (DSAs) are potent antibacterial cyclohexapeptides produced by Streptomyces scopuliridis SCSIO ZJ46. We have identified the 39-kb dsa biosynthetic gene cluster by whole-genome scanning. Composed of 17 open reading frames, the cluster codes for four nonribosomal peptide synthetases and associated resistance, transport, regulatory, and precursor biosynthesis proteins. Heterologous expression of the dsa gene cluster in S. coelicolor M1152 afforded desotamides A and B and the new desotamide G. Cluster identification and its demonstrated amenability to heterologous expression provide the foundation for future mechanistic studies as well as the generation of new and potentially clinically significant DSA analogues. |
| 学科主题 | Plant Sciences; Pharmacology & Pharmacy |
| 原文出处 | 0163-3864 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14841]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Li, Qinglian 2.Song, Yongxiang 3.Qin, Xiangjing 4.Zhang, Xing 5.Sun, Aijun 6.Ju, Jianhua] Chinese Acad Sci, South China Sea Inst Oceanol, RNAM Ctr Marine Microbiol, CAS Key Lab Trop Marine Bioresources & Ecol,Guang, Guangzhou 510301, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Qinglian,Song, Yongxiang,Qin, Xiangjing,et al. Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host[J]. JOURNAL OF NATURAL PRODUCTS,2015,78(4):944-948. |
| APA | Li, Qinglian,Song, Yongxiang,Qin, Xiangjing,Zhang, Xing,Sun, Aijun,&Ju, Jianhua.(2015).Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host.JOURNAL OF NATURAL PRODUCTS,78(4),944-948. |
| MLA | Li, Qinglian,et al."Identification of the Biosynthetic Gene Cluster for the Anti-infective Desotamides and Production of a New Analogue in a Heterologous Host".JOURNAL OF NATURAL PRODUCTS 78.4(2015):944-948. |
入库方式： OAI收割
来源：南海海洋研究所
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