Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594
文献类型：期刊论文
| 作者 | Song, Yongxiang1; Liu, Guangfu1; Li, Jie1; Huang, Hongbo1; Zhang, Xing1; Zhang, Hua1; Ju, Jianhua1 |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2015 |
| 卷号 | 13期号:3页码:1304-1316 |
| 通讯作者 | songx@scsio.ac.cn ; 454143108@qq.com ; lijietaren@yeah.net ; huanghb@scsio.ac.cn ; beishidazhangxing@163.com ; zhanghuahh11@126.com ; jju@scsio.ac.cn |
| 英文摘要 | Two new C-glycoside angucyclines, marangucycline A (1) and marangucycline B (2), along with three known compounds, dehydroxyaquayamycin (3), undecylprodigiosin (4) and metacycloprodigiosin (5), have been identified as products of the deep-sea sediment strain Streptomyces sp. SCSIO 11594. New structures were elucidated on the basis of HRESIMS, 1D and 2D NMR analyses and comparisons to previously reported datasets. Compounds 2 and 4 displayed in vitro cytotoxicity against four cancer cell lines A594, CNE2, HepG2, MCF-7 superior to those obtained with cisplatin, the positive control. Notably, compound 2 bearing a keto-sugar displayed significant cytotoxicity against cancer cell lines with IC50 values ranging from 0.24 to 0.56 mu M; An IC50 value of 3.67 mu M was found when using non-cancerous hepatic cell line HL7702, demonstrating the cancer cell selectivity of 2. Compounds 1-3 were proved to have weak antibacterial activities against Enterococcus faecalis ATCC29212 with an MIC value of 64.0 mu g/mL. Moreover, 3 displayed selective antibacterial activity against methicillin-resistant Staphylococcus epidermidis shhs-E1 with an MIC value of 16.0 mu g/mL. |
| 学科主题 | Pharmacology & Pharmacy |
| 原文出处 | 1660-3397 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14855]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Song, Yongxiang 2.Li, Jie 3.Huang, Hongbo 4.Zhang, Xing 5.Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China 6.[Liu, Guangfu 7.Zhang, Hua] Guangdong Med Coll, Guangdong Prov Key Lab Med Mol Diagnost, Inst Clin Lab Med, Dept Clin Biochem, Dongguan 523808, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Yongxiang,Liu, Guangfu,Li, Jie,et al. Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594[J]. MARINE DRUGS,2015,13(3):1304-1316. |
| APA | Song, Yongxiang.,Liu, Guangfu.,Li, Jie.,Huang, Hongbo.,Zhang, Xing.,...&Ju, Jianhua.(2015).Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594.MARINE DRUGS,13(3),1304-1316. |
| MLA | Song, Yongxiang,et al."Cytotoxic and Antibacterial Angucycline- and Prodigiosin- Analogues from the Deep-Sea Derived Streptomyces sp. SCSIO 11594".MARINE DRUGS 13.3(2015):1304-1316. |
入库方式： OAI收割
来源：南海海洋研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。