Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis
文献类型：期刊论文
| 作者 | Gui, Chun1; Li, Qinglian1; Mo, Xuhua1; Qin, Xiangjing1; Ma, Junying1; Ju, Jianhua1 |
| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2015 |
| 卷号 | 17期号:3页码:628-631 |
| 通讯作者 | jju@scsio.ac.cn |
| 英文摘要 | Bioinformatic analyses indicate that TrdC, SlgL, LipX(2), KirHI, and FacHI belong to a group of highly homologous proteins involved in biosynthesis of actinomycete-derived tirandamycin B, streptolydigin, alpha-lipomycin, kirromycin, and factumycin, respectively. However, assignment of their biosynthetic roles has remained elusive. Gene inactivation and complementation, in vitro biochemical assays with synthetic analogues, point mutations, and phylogenetic tree analyses reveal that these proteins represent a new family of Dieckmann cyclases that drive tetramic acid and pyridone scaffold biosynthesis. |
| 学科主题 | Chemistry |
| 原文出处 | 1523-7060 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14863]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Gui, Chun 2.Li, Qinglian 3.Mo, Xuhua 4.Qin, Xiangjing 5.Ma, Junying 6.Ju, Jianhua] Chinese Acad Sci, CAS Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med, RNAM Ctr Marine Microbiol,South China Sea Inst Oc, Guangzhou 510301, Guangdong, Peoples R China 7.[Gui, Chun] Univ Chinese Acad Sci, Beijing 110039, Peoples R China 8.[Mo, Xuhua] Qingdao Agr Univ, Sch Life Sci, Shandong Key Lab Appl Mycol, Qingdao 266109, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gui, Chun,Li, Qinglian,Mo, Xuhua,et al. Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis[J]. ORGANIC LETTERS,2015,17(3):628-631. |
| APA | Gui, Chun,Li, Qinglian,Mo, Xuhua,Qin, Xiangjing,Ma, Junying,&Ju, Jianhua.(2015).Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis.ORGANIC LETTERS,17(3),628-631. |
| MLA | Gui, Chun,et al."Discovery of a New Family of Dieckmann Cyclases Essential to Tetramic Acid and Pyridone-Based Natural Products Biosynthesis".ORGANIC LETTERS 17.3(2015):628-631. |
入库方式： OAI收割
来源：南海海洋研究所
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