Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae
文献类型：期刊论文
| 作者 | Liang, Yan-Qiu1; Huang, Guo-Yong1; Ying, Guang-Guo1; Liu, Shuang-Shuang1; Jiang, Yu-Xia1; Liu, Shan1 |
| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
 |
| 出版日期 | 2015 |
| 卷号 | 167页码:101-107 |
| 关键词 | Gene transcription Hypothalamic-pituitary-thyroid axis Norgestrel Progesterone |
| 通讯作者 | guangguo.ying@gmail.com |
| 英文摘要 | The aim of this study was to investigate the effects of progestins on the hypothalamic-pituitary-thyroid (HPT) axis in the early stage of zebrafish. Zebrafish embryos were exposed to progesterone (P4) or norgestrel (NGT) at 5, 50 and 100 ng L-1 for 144 h post fertilization (hpf), and the transcriptional levels of target genes along the hypothalamic-pituitary-thyroid axis were determined daily. The results showed that P4 had only minor effects on the mRNA expression of thyroglobulin (Tg), iodothyronine deiodinase type I (Dio1) and thyroid hormone receptor beta (Thrb) genes. Similarly, the effects of NGT on transcripts of thyrotropin-releasing hormone (Trh), Dio1, iodothyronine deiodinase type II (Dio2) and thyroid hormone receptor alpha (Thra) genes were generally low. In addition, NGT resulted in some alterations of Tg and Thrb transcripts at different time points. However, a strong induction of Nis mRNA by P4 and NGT was observed in zebrafish embryos-larvae. The overall results showed that besides Nis no effects on the hypothalamic-pituitary-thyroid (HPT) axis are observed following exposure to P4 and NGT, which imply that both P4 and NGT have potential effects on the thyroid endocrine system by inducing transcript of Nis gene during the early stage of zebrafish. (C) 2014 Elsevier Inc All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Endocrinology & Metabolism; Toxicology; Zoology |
| 原文出处 | 1532-0456 |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/14893]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 作者单位 | 1.[Liang, Yan-Qiu 2.Huang, Guo-Yong 3.Ying, Guang-Guo 4.Liu, Shuang-Shuang 5.Jiang, Yu-Xia 6.Liu, Shan] Chinese Acad Sci, Guangzhou Inst Geochem, State Key Lab Organ Geochem, Guangzhou 510640, Guangdong, Peoples R China 7.[Liu, Shan] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine BioResources Sustainable Utilizat, Guangzhou 510301, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liang, Yan-Qiu,Huang, Guo-Yong,Ying, Guang-Guo,et al. Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2015,167:101-107. |
| APA | Liang, Yan-Qiu,Huang, Guo-Yong,Ying, Guang-Guo,Liu, Shuang-Shuang,Jiang, Yu-Xia,&Liu, Shan.(2015).Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,167,101-107. |
| MLA | Liang, Yan-Qiu,et al."Progesterone and norgestrel alter transcriptional expression of genes along the hypothalamic-pituitary-thyroid axis in zebrafish embryos-larvae".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 167(2015):101-107. |
入库方式： OAI收割
来源：南海海洋研究所
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