Synthesis and antibacterial evaluation of hamacanthin B analogues
文献类型：期刊论文
| 作者 | Kim, Ahhyun; Kim, Min Jeong; Noh, Tae Hwan; Hong, Jongki; Liu, Yonghong; Wei, Xiaoyi; Jung, Jee H. |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2016 |
| 卷号 | 26期号:20页码:5013-5017 |
| 关键词 | Hamacanthin B Bisindole alkaloids MRSA pyruvate kinase Chiral separation |
| 通讯作者 | Jung, JH (reprint author), Pusan Natl Univ, Coll Pharm, Busan 609735, South Korea. |
| 英文摘要 | Hamacanthins are a class of antibacterial bisindole alkaloids isolated from marine sponges. Based on structure-activity relationships and in silico MRSA PK binding analysis of these bisindole alkaloids, the authors designed new hamacanthin B derivatives and evaluated their antibacterial activities against drug-resistant pathogens. Racemates of the synthetic products were resolved into their enantiomers by chiral separation using a cellulose column, and antibacterial activities were compared. Unsaturation of the central heterocyclic ring structure and bromine substitution at the indole moiety were found to enhance the antibacterial activities of hamacanthin B analogues. (C) 2016 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Chemistry |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/15275]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Kim, Ahhyun,Kim, Min Jeong,Noh, Tae Hwan,et al. Synthesis and antibacterial evaluation of hamacanthin B analogues[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(20):5013-5017. |
| APA | Kim, Ahhyun.,Kim, Min Jeong.,Noh, Tae Hwan.,Hong, Jongki.,Liu, Yonghong.,...&Jung, Jee H..(2016).Synthesis and antibacterial evaluation of hamacanthin B analogues.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(20),5013-5017. |
| MLA | Kim, Ahhyun,et al."Synthesis and antibacterial evaluation of hamacanthin B analogues".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.20(2016):5013-5017. |
入库方式： OAI收割
来源：南海海洋研究所
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