A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66
文献类型：期刊论文
| 作者 | Huang, Huiming; Li, Huayue; Qiu, Yanhong; Hou, Lukuan; Ju, Jianhua; Li, Wenli |
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2016 |
| 卷号 | 14期号:10页码:184 |
| 关键词 | deepsea-derived Streptomyces dioic acid wblA(so) |
| 通讯作者 | Li, WL (reprint author), Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ, Qingdao 266003, Peoples R China. ; Li, WL (reprint author), Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266237, Peoples R China. |
| 英文摘要 | The wblA(so) gene functions as a global regulatory gene in a negative manner in deepsea-derived Streptomyces somaliensis SCSIO ZH66. A new dioic acid (1) as well as two known butenolides (2 and 3) were isolated from the wblA(so) mutant strain of S. somaliensis SCSIO ZH66. The structure of 1 was elucidated by a combination of spectroscopic analyses, including MS and NMR techniques. In the cell growth inhibitory evaluation, compound 3 exhibited moderate activity against the human hepatic carcinoma cell line (Huh7.5) with an IC50 value of 19.4 g/mL, while compounds 1 and 2 showed null activity up to 100 g/mL. |
| 学科主题 | Pharmacology & Pharmacy |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/15281]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Huang, Huiming,Li, Huayue,Qiu, Yanhong,et al. A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66[J]. MARINE DRUGS,2016,14(10):184. |
| APA | Huang, Huiming,Li, Huayue,Qiu, Yanhong,Hou, Lukuan,Ju, Jianhua,&Li, Wenli.(2016).A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66.MARINE DRUGS,14(10),184. |
| MLA | Huang, Huiming,et al."A New Dioic Acid from a wbl Gene Mutant of Deepsea-Derived Streptomyces somaliensis SCSIO ZH66".MARINE DRUGS 14.10(2016):184. |
入库方式： OAI收割
来源：南海海洋研究所
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