Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration
文献类型：期刊论文
| 作者 | Feng, J-B; Huang, D-R; Zhong, M.; Liu, P.; Dong, J-D |
| 刊名 | JOURNAL OF FISH DISEASES
 |
| 出版日期 | 2016 |
| 卷号 | 39期号:7页码:833-843 |
| 关键词 | distribution elimination florfenicol florfenicol amine grouper pharmacokinetics |
| 通讯作者 | Feng, JB (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Appl Marine Biol Guangdong Prov, Key Lab Trop Marine Bioresources & Ecol LMB, Guangzhou 510301, Guangdong, Peoples R China. ; Feng, JB (reprint author), Chinese Acad Sci, South China Sea Inst Oceanol, Chinese Acad Sci LAMB, Sanya, Peoples R China. |
| 中文摘要 | Pharmacokinetics and elimination of florfenicol and florfenicol amine in grouper held in sea water at 23.3 +/- 0.8 degrees C were studied using HPLC method after they were given a single peroral dose of florfenicol at 24mgkg(-1) body weight. Florfenicol was rapidly absorbed from intestine and distributed extensively to all the tissues examined. The maximum concentrations (C-max, gg(-1) or gmL(-1)) in plasma and tissues were observed at 2-6h (the time to reach maximum concentration, T-max) except for bile (T-max=24h) and were in the order of intestine (52.02 +/- 25.07)>bile (49.41 +/- 28.16)>gill (45.12 +/- 11.10)>plasma (28.28 +/- 5.43)>liver (21.97 +/- 12.08)>muscle (21.63 +/- 6.12)>kidney (20.88 +/- 11.28)>skin (19.10 +/- 5.88). The drug distribution level was higher in plasma than in extravascular tissues except for bile, based on the ratios of the area under concentration-time curve between tissue and plasma (AUC(tissue/plasma)). The elimination of florfenicol was rapid in fish, and the corresponding half-lives (T-1/2) in the order of magnitude were bile (13.92h)>muscle or liver (12.31h)>skin (11.77h)>plasma (11.57)>gill (11.04h)> intestine (10.55h)>kidney (10.05h). The delayed T-max, lower C-max and longer T-1/2 for florfenicol amine compared with florfenicol were measured in grouper. |
| 学科主题 | Fisheries; Marine & Freshwater Biology; Veterinary Sciences |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/15391]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Feng, J-B,Huang, D-R,Zhong, M.,et al. Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration[J]. JOURNAL OF FISH DISEASES,2016,39(7):833-843. |
| APA | Feng, J-B,Huang, D-R,Zhong, M.,Liu, P.,&Dong, J-D.(2016).Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration.JOURNAL OF FISH DISEASES,39(7),833-843. |
| MLA | Feng, J-B,et al."Pharmacokinetics of florfenicol and behaviour of its metabolite florfenicol amine in orange-spotted grouper (Epinephelus coioides) after oral administration".JOURNAL OF FISH DISEASES 39.7(2016):833-843. |
入库方式： OAI收割
来源：南海海洋研究所
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