Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30
文献类型：期刊论文
| 作者 | Zhou, Xuefeng; Fang, Wei; Tan, Suiyi; Lin, Xiuping; Xun, Tianrong; Yang, Bingjie; Liu, Shuwen; Liu, Yonghong |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2016 |
| 卷号 | 26期号:2页码:361-365 |
| 关键词 | Aspergillus niger Aspernigrins Malformin C HIV-1 SF162 |
| 通讯作者 | Liu, SW (reprint author), South Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, State Key Lab Organ Failure Res, Guangzhou 510515, Guangdong, Peoples R China. |
| 中文摘要 | Two new 2-benzylpyridin-4-one containing metabolites, aspernigrins C (3) and D (4), together with six known compounds (1, 2, and 5-8), were isolated from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30. The structures of the new compounds were determined by NMR, MS, and optical rotation analyses. All the isolated compounds were evaluated for their inhibitory activities against infection with HIV-1 SF162 in TZM-bl cells. Malformin C (5) showed the strongest anti-HIV-1 activity with IC50 of 1.4 +/- 0.06 mu M (selectivity index, 11.4), meanwhile aspernigrin C (3) also exhibited potent activity with IC50 of 4.7 +/- 0.4 mu M (selectivity index, 7.5). (C) 2015 Elsevier Ltd. All rights reserved. |
| 学科主题 | Pharmacology & Pharmacy; Chemistry |
| 源URL | [http://ir.scsio.ac.cn/handle/344004/15510]  |
| 专题 | 南海海洋研究所_中科院海洋生物资源可持续利用重点实验室 |
| 推荐引用方式 GB/T 7714 | Zhou, Xuefeng,Fang, Wei,Tan, Suiyi,et al. Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2016,26(2):361-365. |
| APA | Zhou, Xuefeng.,Fang, Wei.,Tan, Suiyi.,Lin, Xiuping.,Xun, Tianrong.,...&Liu, Yonghong.(2016).Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,26(2),361-365. |
| MLA | Zhou, Xuefeng,et al."Aspernigrins with anti-HIV-1 activities from the marine-derived fungus Aspergillus niger SCSIO Jcsw6F30".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 26.2(2016):361-365. |
入库方式： OAI收割
来源：南海海洋研究所
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